海南医学院学报2017，Vol.23Issue(18)：2514-2516,2520,4.DOI:10.13210/j.cnki.jhmu.20170906.004
藻酸钙敷料对肛周脓肿术后创面中细胞因子含量、胶原合成-降解平衡、凋亡基因表达的影响
Effect of calcium alginate dressing on the cytokine contents, collagen synthesis-degradation balance and apoptosis gene expression in the wound after perianal abscess surgery
摘要
Abstract
Objective:To study the effect of calcium alginate dressing on the cytokine contents,collagen synthesis-degradation balance and apoptosis gene expression in the wound after perianal abscess surgery.Methods:Patients with perianal abscess who received surgical resection in the Eighth Hospital of Wuhan between May 2014 and February 2017 were selected and randomly divided into the group A who received calcium alginate dressing combined with kangfuxin solution and recombinant human epidermal growth factor for dressing change and the group B who received kangfuxin solution and recombinant human epidermal growth factor for dressing change.3 days,6 days and 9 days after dressing change,appropriate amount of wound tissue was collected to determine the expression of cytokines,collagen metabolites and apoptosis genes.Results:3 days,6 days and 9 days after dressing change,TGF-[β1,Smad3,EGF and bFGF protein expression as well as Col-Ⅰ,Col-Ⅱ,Col-Ⅲ,TIMP1 and TIMP2 protein expression in wounds of both groups of patients were increasing while Fas,FasL,Bax and Caspase-3 protein expression were decreasing,and TGF-β1,Smad3,EGF and bFGF protein expression as well as Col-Ⅰ,Col-Ⅱ,ColⅢ,TIMP1 and TIMP2 protein expression in wounds of group A were significantly higher than those of group B while Fas,FasL,Bax and Caspase-3 protein expression were significantly lower than those of group B.Conclusion:Calcium alginate dressing for wound dressing after perianal abscess surgery an increase the pro-proliferation cytokine expression,adjust the collagen synthesis-degradation balance and inhibit apoptosis,and it is conducive to wound healing.关键词
肛周脓肿/藻酸钙敷料/细胞因子/胶原/细胞凋亡Key words
Perianal abscess/Calcium alginate dressing/Cytokine/Collagen/Apoptosis分类
医药卫生引用本文复制引用
卢勇,黄成龙,俞凡,徐跃军..藻酸钙敷料对肛周脓肿术后创面中细胞因子含量、胶原合成-降解平衡、凋亡基因表达的影响[J].海南医学院学报,2017,23(18):2514-2516,2520,4.基金项目
2013湖北省卫计委面上项目(JX6B105) （JX6B105）
This study was supported by Surface Project of Health and Family Planning Commission of Hubei Province in 2013 (JX6B105). （JX6B105）
