海南医学院学报2017，Vol.23Issue(18)：2528-2530,2534,4.DOI:10.13210/j.cnki.jhmu.20170920.009
米非司酮对子宫内膜异位症患者异位内膜组织中侵袭基因、凋亡基因表达的影响
Effect of mifepristone on invasion gene and apoptosis gene expression in ectopic endometrial tissue of patients with endometriosis
摘要
Abstract
Objective:To study the effect of mifepristone on invasion gene and apoptosis gene expression in ectopic endometrial tissue of patients with endometriosis.Methods:Patients with endometriosis who were treated in Hospital between March 2015 and June 2017 were selected as the research subjects and randomly divided into two groups,mifepristone group received mifepristone therapy 3 months before surgery,and control group received no special treatment.The endometriosis lesions were collected after surgical resection to determine the expression of invasion and apoptosis genes.Results=β-catenin,GSK33,uPA,NF-kB p65,OPN,Ki-67,c-IAP1,Bcl-2,Livin and Id-1 protein expression in endometriosis lesions of mifepristone group were significantly lower than those of control group while PTEN,Smac,Bax and Fas protein expression were significantly higher than those of control group,Conclusion:Preoperative mifepristone therapy can inhibit cell invasion and promote cell apoptosis in endometriosis lesion.关键词
子宫内膜异位症/米非司酮/侵袭基因/凋亡基因Key words
Endometriosis/Mifepristone/Invasion gene/Apoptosis gene分类
医药卫生引用本文复制引用
谢伟..米非司酮对子宫内膜异位症患者异位内膜组织中侵袭基因、凋亡基因表达的影响[J].海南医学院学报,2017,23(18):2528-2530,2534,4.基金项目
武汉市卫生局项目(2015CD06) （2015CD06）
This study was supported by Project of Health Bureau of Wuhan City (2015CD06). （2015CD06）
