海南医学院学报2017，Vol.23Issue(18)：2566-2569,4.DOI:10.13210/j.cnki.jhmu.20170920.024
新辅助化疗方案治疗局部晚期宫颈癌的疗效及安全性评价
Efficacy and safety evaluation of new adjuvant chemotherapy in the treatment of locally advanced cervical cancer
摘要
Abstract
Objective:To explore the efficacy and safety of different neoadjuvant chemotherapy (NACT) to treat cerical cervical cancer (LACC).Methods:68 cases of LACC treated in the hospital from April 2015 to August 2016 were divided into observation groups (n =34) and control group (n =34).Observation group USES the west he plus oxaliplatin into more chemotherapy regimens (DTX + OXA),control group adopts paclitaxel + cisplatin chemotherapy regimens (TAX + DDP) and 21 d of 1 cycle,a total of treatment 2 cycles,end of the treatment after laparoscopic extensive hysterectomy,pelvic lymph node cleaning operation and the lymph node sampling technique by abdominal aorta.Observation of the recent results of the two groups and the adverse reactions;Pathological evaluation of the postoperative specimens of the two groups;Two groups of peripheral blood T lymphocyte subgroups and NK cell changes were detected and compared.Results:the observation group ORR and DCR were 47.09％,91.18％,and the control group was 44.12％,85.29％,and no significant difference between the two groups (P＞0.05).Compared with before treatment,after treatment for 2 set of CD4+,CD8+ and NK cells were significantly reduced,CD4+/ CD8+ ratio increased significantly (P＜0.01),but there was no significant difference between two groups (P ＞0.05).There was no significant difference in the proportion of patients with PCR,PR1,PR2,and PR2 after postoperative pathology (P＞0.05).At the same time,there was no significant difference between cervical infiltration depth,surgical incisiveness,and palatial infiltration and pelvic lymph node metastasis (P＞0.05).The percentage of patients with baldness,gastrointestinal reaction and renal toxicity was lower than the control group (P ＜0.05).But the ratio of peripheral neurotoxicity was higher than the control group (P＜0.05 or P＜0.01).Conclusions:laparoscopic surgery using DTX + OXA LACC and TAX + DDP chemotherapy regimen for the recent curative effect,but DTX + OXA solution general toxic effects on the patients is relatively low,good security,worth clinical it is recommended to use.关键词
局部晚期宫颈癌/新辅助化疗/多西他赛/奥沙利铂/免疫功能Key words
Cervical cervical cancer/Neoadjuvant chemotherapy/Dorsey him/Oxaliplatin into/The immune function分类
医药卫生引用本文复制引用
刘玉娜,贺鹏,韩文红,陈丽..新辅助化疗方案治疗局部晚期宫颈癌的疗效及安全性评价[J].海南医学院学报,2017,23(18):2566-2569,4.基金项目
2016年保定市科学技术研究与发现指导计划项目(16ZF103) （16ZF103）
It is supported by 2016 Scientific and Technological Research and Discovery Guidance Project in Baoding City (16ZF103). （16ZF103）
