海南医学院学报2017，Vol.23Issue(18)：2589-2592,4.DOI:10.13210/j.cnki.jhmu.20170906.002
针灸联合药物治疗对脑梗死康复期神经细胞因子分泌及氧化应激状态的影响
Effect of acupuncture combined with drug therapy on the nerve cytokine secretion and oxidative stress in convalescence of cerebral infarction
摘要
Abstract
Objective:To explore the effect of acupuncture combined with drug therapy on the nerve cytokine secretion and oxidative stress in convalescence of cerebral infarction.Methods:A total of 118 patients in convalescence of cerebral infarction who were treated in the affiliated hospital of our school between August 2014 and December 2016 were divided into control group (n =59) and observation group (n =59) according to the random number table method.Control group received routine drug therapy,and the observation group received acupuncture combined with drug therapy.The differences in serum levels of neurotrophic factors,nerve injury factors and oxidative stress indexes were compared between the two groups before and after treatment.Results:The differences in serum levels of neurotrophic factors,nerve injury factors and oxidative stress indexes were not statistically significant between the two groups before treatment (P＞0.05).After treatment,serum neurotrophic factors IGF-1,BDNF and NGF levels of observation group were higher than those of control group;nerve injury factors S-100β,NSE,GFAP and UCH-L1 levels were lower than those of control group;oxidative stress indexes MDA,AOPPs and LHP levels were lower than those of control group while SOD and GSH-Px levels were higher than those of control group (P＜0.05).Conclusion:Acupuncture combined with drug therapy can effectively optimize the nerve function,reduce the nerve injury and suppress the systemic oxidative stress response of patients in convalescence of cerebral infarction.关键词
脑梗死康复期/针灸/神经细胞因子/氧化应激Key words
Convalescence of cerebral infarction/Acupuncture/Nerve cytokines/Oxidative stress分类
医药卫生引用本文复制引用
戴筱杰..针灸联合药物治疗对脑梗死康复期神经细胞因子分泌及氧化应激状态的影响[J].海南医学院学报,2017,23(18):2589-2592,4.基金项目
广西职业教育教学改革研究项目(GXZZJG2016B024) （GXZZJG2016B024）
This study was supported by Project of Vocational Education and Teaching Reform Research in Guangxi Province (GXZZJG2016B024). （GXZZJG2016B024）
