海南医学院学报2017，Vol.23Issue(19)：2645-2648,4.DOI:10.13210/j.cnki.jhmu.20170927.007
多粘菌素静滴联合雾化吸入对鲍曼不动杆菌感染性VAP患者炎症反应进程的影响
Influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP
摘要
Abstract
Objective:To explore the influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP .Methods:60 patients with Acineto-bacter baumannii infectious VAP who received hospitalization in the hospital between January 2014 and January 2017 were col-lected and divided into control group and observation group by random number table ,30 cases in each group .Control group of patients received conventional therapy ,observation group of patients received conventional therapy + polymyxin intravenous drip combined with aerosol inhalation ,and the therapy lasted for 2 weeks .The differences in serum levels of acute phase pro-teins ,oxidative stress indexes and inflammatory response indexes were compared between the two groups before and after treatment .Results:Before treatment ,the differences in serum levels of acute phase proteins ,oxidative stress indexes and in-flammatory response indexes were not statistically significant between the two groups of patients (P>00.5) .After 2 weeks of treatment ,serum acute phase protein PA level of observation group was higher than that of control group while CRP and CER levels were lower than those of control group ;serum oxidative stress indexes MDA and LHP levels were lower than those of control group while SOD level was higher than that of control group ;serum inflammatory response indexes IL-1 ,IL-6 ,IL-8 and TNF-αlevels were lower than those of control group (P<00.5) .Conclusion:Polymyxin intravenous drip combined with aerosol inhalation can inhibit the systemic inflammatory response process and promote the disease recovery in patients with Acinetobacter baumannii infectious VAP .关键词
鲍曼不动杆菌感染性VAP/多粘菌素/炎症反应Key words
Acinetobacter baumannii infectious VAP/polymyxin/inflammatory response分类
医药卫生引用本文复制引用
汪毓君,喻莉..多粘菌素静滴联合雾化吸入对鲍曼不动杆菌感染性VAP患者炎症反应进程的影响[J].海南医学院学报,2017,23(19):2645-2648,4.基金项目
It is supported by Science Research Project of Health and Family Planning Bureau of Wuhan City (wx12c35) .武汉市卫生局科研项目(wx12c35) （wx12c35）
