海南医学院学报2017，Vol.23Issue(19)：2664-2667,4.DOI:10.13210/j.cnki.jhmu.20170927.005
右美托咪定联合舒芬太尼对腹腔镜胃肠穿孔修补术后患者血流动力学、应激反应及炎性因子水平的影响
Effects of dexmedetomidine combined with sufentanil on hemorheology ,stress response and inflammatory cytokines in patients undergoing laparoscopic gastrointestinal perforation
摘要
Abstract
Objective:To observe the clinical application of dexmedetomidine combined with sufentanil anesthesia in pa-tients undergoing laparoscopic gastrointestinal perforation repair ,and the changes of hemodynamics ,stress response and in-flammatory factors were analyzed before and after operation .Methods:102 patients with laparoscopic gastrointestinal perfora-tion were randomly divided into control group (n=51) and observation group (n=51) according to the lottery method .The control group was given anesthesia with sufentanil ,and the observation group was given dexmedetomidine combined with sufentanil anesthesia ,and the other anesthesia drugs were the same .The hemodynamics ,serum stress response and inflamma-tory factor levels were measured in all subjects .Results:At T1 and T2 ,there was no significant difference between the two groups in hemodynamics (P>00.5) .At T3 ,and T4 ,HR ,SBP ,and DBP in the observation group were significantly lower than those in the control group (P<00.5) ,and which compared with the observation group were no significant difference (P>00.5) .At T3 ,and T4 ,the HR ,SBP and DBP of the control group were significantly higher than those of T1 (P<0 .05) . There was no significant difference in serum stress hormone between the two groups before surgery (P>00.5) .After surgery 24 hours ,two groups of serum ACTH ,Cor and ALD levels were higher than those of preoperative ,and the observation group was significantly lower than those of the control group (P<00.5) .There was no significant difference in serum inflammatory cytokines between the two groups before surgery (P>00.5) .After surgery 24 hours ,the levels of serum IL-10 and TNF-αin the two groups were higher than those before operation (P<0 .05) ,and the observation group was significantly lower than those of the control group (P<00.5) .Conclusion:The combination of dexmedetomidine and sufentanil anesthesia can maintain the hemodynamic stability of patients ,reduce the stress response and serum inflammatory factor concentration ,which is one of the potential effective anesthesia compound .关键词
右美托咪定/舒芬太尼/腹腔镜胃肠穿孔修补术/血流动力学/应激反应/炎性因子Key words
Dexmedetomidine/sufentanil/laparoscopic gastrointestinal perforation repair/hemodynamics/stress re-sponse/inflammatory cytokines分类
医药卫生引用本文复制引用
王斌,赵星,孙艳玲..右美托咪定联合舒芬太尼对腹腔镜胃肠穿孔修补术后患者血流动力学、应激反应及炎性因子水平的影响[J].海南医学院学报,2017,23(19):2664-2667,4.基金项目
It is supported by Institute-level Project of Shiyan Taihe Hospital in Hubei Province (2016JJXM054) .湖北省十堰市太和医院院级课题(2016JJXM054) （2016JJXM054）
