海南医学院学报2017，Vol.23Issue(19)：2690-2693,4.DOI:10.13210/j.cnki.jhmu.20170927.003
纳布啡超前镇痛联合罗哌卡因局部浸润对小儿术后切口疼痛、应激反应及免疫功能的影响
Effect of nalbuphine preemptive analgesia combined with ropivacaine local infiltration on postoperative incision pain ,stress response and immune function in children
摘要
Abstract
Objective:To study the effect of nalbuphine preemptive analgesia combined with ropivacaine local infiltration on postoperative incision pain ,stress response and immune function in children .Methods:Children who received selective lapa-rotomy in Mianyang Central Hospital between August 2015 and August 2017 were selected and randomly divided into control group ,nalbuphine group (N group) ,ropivacaine group (R group) and nalbuphine + ropivacaine group (N+ R group) .The levels of pain and stress-related mediators in serum and the levels of immune cells in peripheral blood were detected before op-eration and 24 hours after operation .Results:24 hours after operation ,serum Cor ,NE ,MDA ,SP ,PGE2 ,BK ,NPY ,TNF-α,IL-6 and IL-10 levels of four groups of children were significantly higher than those before operation while serum SOD and CAT levels as well as peripheral blood CD3+ ,CD4+ and CD8+ T cell levels were significantly lower than those before opera-tion;serum Cor ,NE ,MDA ,SP ,PGE2 ,BK ,NPY ,TNF-α,IL-6 and IL-10 levels of N group ,R group and N+ R group were significantly lower than those of control group while serum SOD and CAT levels as well as peripheral blood CD 3+ ,CD4+and CD8+ T cell levels were significantly higher than those of control group ;serum Cor ,NE ,MDA ,SP ,PGE2 ,BK ,NPY , TNF-α,IL-6 and IL-10 levels of N+R group were significantly lower than those of N group and R group while serum SOD and CAT levels as well as peripheral blood CD3+ ,CD4+ and CD8+ T cell levels were significantly higher than those of N group and R group .Conclusion:Nalbuphine preemptive analgesia combined with ropivacaine local infiltration can reduce the postoperative incision pain and stress response and improve the immune function in children .Key words :关键词
纳布啡/罗哌卡因/疼痛/应激/免疫应答Key words
Nalbuphine/ropivacaine/pain/stress/immune response分类
医药卫生引用本文复制引用
杨宇,易庆军,李秀泽,夏氢,张永洪..纳布啡超前镇痛联合罗哌卡因局部浸润对小儿术后切口疼痛、应激反应及免疫功能的影响[J].海南医学院学报,2017,23(19):2690-2693,4.基金项目
It is supported by 2017 Science Research Project of Health and Family Planning Commission of Sichuan Province (Popular Application Project) (17PJ232) . 2017年四川省卫生和计划生育委员会科研课题(普及应用项目)(17PJ232) （Popular Application Project）
