海南医学院学报2017，Vol.23Issue(19)：2720-2723,4.DOI:10.13210/j.cnki.jhmu.20170926.015
替吉奥联合奥沙利铂方案治疗老年胃癌对患者血清肿瘤标志物、基质金属蛋白酶及免疫功能的影响
Effect of S-1 combined with oxaliplatin on serum tumor markers ,matrix metalloproteinase and immune function in elderly patients with gastric cancer
摘要
Abstract
Objective:To investigate the effect of Compound Tegafur and Oteracil Potassium Sustained Capsules (S-1) combined with oxaliplatin chemotherapy on serum tumor marker matrix metalloproteinase and immune function in elderly pa-tients with gastric cancer .Methods:According to the random data table ,80 cases of elderly patients with gastric cancer were divided into control group and observation group (n=40) ,patients in the control group were treated with oxaliplatin combined with Capecitabine Tablets ,and the observation group patients were treated with S-1 combined with oxaliplatin ,all treated for 6 cycles ,before and after treatment ,levels of serum tumor markers ,matrix metalloproteinase and immune function were com-pared between the two groups .Results:Before treatment ,there was no significant difference in the levels of CEA ,CA125 , CA19-9 ,MMP-2 ,MMP-9 ,CD3+ ,CD4+ ,CD8+ and CD4+ /CD8+ between the two groups (P>00.5);After treatment ,the levels of CEA ,CA125 ,CA19-9 ,MMP-2 ,MMP-9 and CD8+ in the two groups were significantly lower than those in the same group before treatment ,and the levels of the observation group[(77.9 ± 27.8)ng/ml ,(225.6 ± 73.1)U/mL ,(134.8 ± 30.5)U/mL ,(578.4 ± 89.3)ng/mL ,(1991.4 ± 673.9)ng/mL and (262.1 ± 41.8)% ] were significantly lower than those in the control group (P<00.5);Compared with the group before treatment ,the levels of CD3+ ,CD4+ and CD4+ /CD8+ in the two groups were significantly increased ,and the observation group [(668.9 ± 58.4)% ,(416.3 ± 52.4)% and (13.7 ± 02.9)]was significant-ly higher than the control group (all P<00.5) .Conclusion:S-1 combined with oxaliplatin chemotherapy can effectively reduce serum tumor markers and matrix metalloproteinase levels ,improve immune function ,has an important clinical value .关键词
胃癌/替吉奥/奥沙利铂/肿瘤标志物/基质金属蛋白酶/免疫功能Key words
S-1/oxaliplatin/gastric cancer/tumor marker/matrix metalloproteinase/immune function分类
医药卫生引用本文复制引用
单永锋,陈艳..替吉奥联合奥沙利铂方案治疗老年胃癌对患者血清肿瘤标志物、基质金属蛋白酶及免疫功能的影响[J].海南医学院学报,2017,23(19):2720-2723,4.基金项目
It is supported by Provincial Open Project for Key Subject of Jiangsu Health and Family Planning Department (KF201512) .江苏省卫生厅重点学科省内开放课题 (K F201512 ) （KF201512）
