解放军医药杂志2017，Vol.29Issue(11)：80-83,4.DOI:10.3969/j.issn.2095-140X.2017.11.021
地塞米松联合异烟肼鞘内注射治疗结核性脑膜炎效果观察
Effect Observation of Dexamethasone Combined with Isoniazid by Intrathecal Injection in Treatment of Patients with Tuberculous Meningitis
摘要
Abstract
Objective To investigate effect of Dexamethasone combined with Isoniazid by intrathecal injection in treatment of patients with tuberculous meningitis (TBM) and its effect on cerebrospinal fluid.Methods A total of 93TBM patients admitted during March 2015 and February 2017 were divided into observation group (n =47) and control group (n =46) according to different treatments.All patients received routine anti-tuberculosis treatment.Control group was treated with Dexamethasone by intravenous infusion,while observation group was treated with Dexamethasone by intravenous infusion combined with Isoniazid by intrathecal injection.In two groups,changes of cerebrospinal fluid indexes,returning to normal times of clinical sings and symptoms before and after treatment were observed,and safety was also evaluated.Results The total effective rate in observation group was significantly higher than that in control group(P ＜0.05).After treatment,chlorides and glucose levels in cerebrospinal fluid were significantly increased,while cell numbers and protein levels were significantly decreased compared with those before treatment in two groups,and the improvement conditions in observation group were better than those in control group (P ＞ 0.05,P ＞ 0.01).After treatment,returning to normal times of cerebrospinal fluid indicators,clinical sings and symptoms were significantly shorter in observation group than those in control group (P ＜ 0.01).There was no significant difference in incidence rate of adverse reactions between the two groups (P ＞ 0.05).Conclusion Dexamethasone combined with Isoniazid by intrathecal injection in treatment of patients with tuberculous meningitis may improve normal levels of cerebrospinal fluid and clinical symptoms more quickly with safety.关键词
结核,脑膜/地塞米松/异烟肼/注射,脊髓/脑脊液常规Key words
Tuberculous, meningitis/Dexamethasone/Isoniazid/Injection, spinal/Cerebrospinal fluid routine分类
医药卫生引用本文复制引用
李倩,张建树,孟艺哲..地塞米松联合异烟肼鞘内注射治疗结核性脑膜炎效果观察[J].解放军医药杂志,2017,29(11):80-83,4.基金项目
河北省青年科技课题(20150140) （20150140）
