化工进展2017，Vol.36Issue(12)：4622-4627,6.DOI:10.16085/j.issn.1000-6613.2017-0472
毒死蜱/乙基纤维素微胶囊的制备及其缓释性能
Preparation and sustained release of chlorpyrifos/ethyl cellulose microcapsules
摘要
Abstract
Chlorpyrifos/ethyl cellulose microcapsules were prepared by mulsification-solvent evaporation method with the ethyl cellulose as wall material and the chlorpyrifos as model drug. The structures and morphologies of microcapsules,form of chlorpyrifos were characterized by FTIR,SEM and DSC. The effect of core material ratio,PVA concentration,PVA to SDS mass ratio and stirring speed on loading content(LC) and encapsulation efficiency(EE)werestudied using single factor method. Besides,the effects of core material ratio and PVA concentration on sustained release of chlorpyrifos were also discussed. The results showed that chlorpyrifos/ethyl cellulose microcapsules had a more condensed spherical structure,and the crystalline chlorpyrifos was distributed in microcapsules. When the core material ratio was 2:3,PVA concentration was 1.5%,the mass ratio of PVA:SDS was 3:2 and stirring speed was 1500 r/min,the LC and EE were better,which were 44.41% and 82.42%,respectively. Meanwhile,the microcapsules had good sustained release properties,and their releasing curves could be described by Korsmeyer-Peppas equation indicating that the drug release was controlled by Fick diffusion.关键词
乙基纤维素/毒死蜱/微胶囊/溶剂挥发法/缓释Key words
ethyl cellulose/chlorpyrifos/microcapsules/emulsification-solvent evaporation method/sustained release分类
化学化工引用本文复制引用
徐华,林粤顺,周红军,周艺宇,陈喜,周新华..毒死蜱/乙基纤维素微胶囊的制备及其缓释性能[J].化工进展,2017,36(12):4622-4627,6.基金项目
广东省科技计划(2015A020209197,2015A020209185)、花都区科技计划(HD15CXY002)及广东省大学生创新创业训练计划(201611347048)项目. （2015A020209197,2015A020209185）
