化工进展2017，Vol.36Issue(z1)：398-401,4.DOI:10.16085/j.issn.1000-6613.2017-0086
2-苯基-6-羟基-3-哒嗪酮的合成工艺
Synthetic process of 2-phenyl-6-hyroxy-3-pyridazone
刘欣然 1王文峰 1胡燕飞 1陆勇 1陈天云1
作者信息
- 1. 合肥工业大学化学与化工学院,安徽 合肥 230009
- 折叠
摘要
Abstract
2-phenyl-6-hydroxy-3-pyridazone is a kind of important heterocyclic compound which is an important activity medicine and pesticide intermediates. Phenylhydrazine hydrochloride was synthesized with aniline as raw material by diazotization, reduction reaction. Then, phenylhydrazine hydrochloride was reacted with maleic anhydride to get 2-phenyl-6-hyroxy-3-pyridazone. The effects of technical parameters on the yield of 2-phenyl-6-hyroxy-3-pyridazone were studied through single-factor experimental method,such as raw materials ratio,reaction time and reaction temperature,etc. The optima reaction conditions were determined as follow:n(C6 H7 N):n(NaNO2 ):n(HCl)=1:1.02:2.3,reduction temperature 85℃,reduction time 2h,condensation temperature 100℃,condensation time 3h,the 85%yield of 2-phenyl-6-hyroxy-3-pyridazone could be reached. It show that synthetic is the target product.by melting, IR, NMR and HPLC characterization and analysis.关键词
2-苯基-6-羟基-3-哒嗪酮/苯胺/苯肼盐酸盐/顺丁烯二酸酐/重氮化反应/缩合反应Key words
2-phenyl-6-hyroxy-3-pyridazone/aniline/phenylhydrazine hydrochloride/maleic anhydride/diazotization reaction/condensation reaction分类
化学化工引用本文复制引用
刘欣然,王文峰,胡燕飞,陆勇,陈天云..2-苯基-6-羟基-3-哒嗪酮的合成工艺[J].化工进展,2017,36(z1):398-401,4.
