湖南中医药大学学报2017，Vol.37Issue(2)：149-152,4.DOI:10.3969/j.issn.1674-070X.2017.02.009
清胰逐瘀汤对急性胰腺炎大鼠微循环的影响及其机制
Effects of Qingyi Zhuyu Decoction on Microcirculation of Rats with Acute Pancreatitis and its Mechanism
摘要
Abstract
Objective To explore the effect and mechanism of Qingyi Zhuyu decoction on microcirculation of rats with acute pancreatitis.Methods Fifty-four Wistar rats were randomly divided into sham-operation group,model group,treatment group.The IL-6,TNF-α,serum amylyse (AMS),Prothrombin time (PT),D-dimer (D-D),platelets(PLT) in each group were examined at 8 h after operation.Results Compared with the sham-operation group,the IL-6,TNF-α,AMS,PT and D-D were higher in the model group,but the PLT was lower,the difference was statistically significant (P＜0.01).Compared with the model group,the increased degree of IL-6,TNF-α,AMS,PT and D-D level in treatment group,the reduced degree of PLT were relieved,the difference was statistically significant (P＜0.01).Conclution Qingyi Zhuyu decoction could improve the microcirculation of rats with acute pancreatitis insome extent.Its mechanism was realated to its influence in the inflammatory mediator and coagulation fibrinolysis system of rats with acute pancreatitis,and alleviation of tissues organ's injure caused by microcirculation disturbance.关键词
胰腺炎/微循环/清胰逐瘀汤/白细胞介素6/肿瘤坏死因子α/血浆凝血酶原时间/血浆D二聚体Key words
acute pancreatitis/microcirculation/Qingyi Zhuyu decoction/IL-6/TNF-α/PT/plasma D-dimer分类
医药卫生引用本文复制引用
徐寒,刘欢,陈念,冷大跃..清胰逐瘀汤对急性胰腺炎大鼠微循环的影响及其机制[J].湖南中医药大学学报,2017,37(2):149-152,4.基金项目
湖南省科技厅项目(2013sk3101). （2013sk3101）
