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海洋链霉菌P10-16代谢产物的分离与鉴定

郭俊夫 宗蜜蜜 徐文平 陶黎明

湖南农业大学学报(自然科学版)2017,Vol.43Issue(6):615-619,5.
湖南农业大学学报(自然科学版)2017,Vol.43Issue(6):615-619,5.DOI:10.13331/j.cnki.jhau.2017.06.007

海洋链霉菌P10-16代谢产物的分离与鉴定

Isolation and identification of metabolites from marine Streptomyces viridobrunneus P10-16

郭俊夫 1宗蜜蜜 1徐文平 1陶黎明1

作者信息

  • 1. 华东理工大学药学院,上海 200237
  • 折叠

摘要

Abstract

The secondary metabolites from marine Streptomyces viridobrunneus P10-16 were isolated and identified by silica gel column chromatography and TLC, their structures were elucidated with spectra data analysis of ESI-MS and NMR, and their antifungal activities were tested with the indicator fungus of rice blast. The results showed that five iturins (iturin A-2, A-3, A-4, A-6 and A-7) and DEHP were isolated from marine S. viridobrunneus. Half maximal inhibitory concentration(IC50) and minimum inhibitory concentration(MIC)of iturin A-2 (Po) were 26.471, 62.500μg/mL, while IC50 and MIC of DEHP (Po) were 1.9159, 15.625 μg/mL, respectively.

关键词

海洋链霉菌P10-16/分离/纯化/伊枯草菌素A/结构鉴定/抗菌活性

Key words

marine Streptomyces viridobrunneus P10-16/isolation/purification/iturin A/structure elucidation/antimicrobial activity

分类

生物科学

引用本文复制引用

郭俊夫,宗蜜蜜,徐文平,陶黎明..海洋链霉菌P10-16代谢产物的分离与鉴定[J].湖南农业大学学报(自然科学版),2017,43(6):615-619,5.

基金项目

"十二五"国家科技支撑项目(2011BAE06B04) (2011BAE06B04)

湖南农业大学学报(自然科学版)

OA北大核心CSCDCSTPCD

1007-1032

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