常州大学学报（自然科学版）2017，Vol.29Issue(6)：83-91,9.DOI:10.3969/j.issn.2095-0411.2017.06.012
不同性别小鼠对乙酰氨基酚急性肝损伤的敏感性差异
Different Sensitivity of Acetaminophen-Induced Acute Liver Inj ury in Mice of Different Genders
路燕 1雷宇 2章礼久 3徐德祥1
作者信息
- 1. 安徽医科大学第二附属医院 消化内科,安徽 合肥 230601
- 2. 安徽医科大学 毒理系,安徽 合肥230032
- 3. 安徽医科大学第一附属医院 肿瘤内科,安徽 合肥 230022
- 折叠
摘要
Abstract
Acetaminophen overdose is one of the causes of common clinical drug-induced liver inj ury. However,it may exist difference of APAP-induced liver injury from different genders.Exploring its risk factors have profound significance for clinical treatment of APAP-induced liver inj ury in different populations.It used immature ICR mice and adult ICR mice (males and females ).All mice were divided into two groups:APAP treatment group and control group.APAP treatment group mice were i.p.injected with APAP (300mg/kg),while control group mice were i.p.saline.Serum ALT of adult male mice were higher than adult female mice both at 4h and 24h after APAP injection.Liver necrotic areas of adult male mice were larger than adult female mice.TUNEL assay prompted liver TUNEL positive cells in adult male mice were significantly higher than adult female mice.3-NT expression of liver in adult male mice were significantly higher than adult female mice both at 4h and 24h after APAP inj ection.Futhermore,p-JNK level of adult male mice were significantly higher than adult fe-male mice at 4h after APAP induced.Depletion of GSH in adult male mice were larger than adult fe-male mice.GSSG/GSH ratio of adult male mice were risen higher than adult female mice.GPX and GST activity of adult male mice were lower than adult female mice.Gender differences on APAP-in-duced acute liver inj ury were observed only in adult mice.Adult male mice were more susceptible to hepatotoxicity.关键词
对乙酰氨基酚/肝损伤/性别Key words
acetaminophen/liver inj ury/gender分类
医药卫生引用本文复制引用
路燕,雷宇,章礼久,徐德祥..不同性别小鼠对乙酰氨基酚急性肝损伤的敏感性差异[J].常州大学学报（自然科学版）,2017,29(6):83-91,9.
