临床肝胆病杂志2017，Vol.33Issue(11)：2235-2238,4.DOI:10.3969/j.issn.1001-5256.2017.11.041
原发性胆汁性胆管炎小鼠模型的研究进展
Research advances in the mouse model of primary biliary cholangitis
摘要
Abstract
Primary biliary cholangitis (PBC) is an autoimmune disease characterized by the destruction of interlobular bile ducts and infiltration of inflammatory factors.An increase in anti-mitochondrial antibody is the major feature of PBC and may eventually lead to intrahepatic cholestasis,liver fibrosis,and even liver cirrhosis.The pathogenesis of this disease remains unclear,and there is no ideal treatment regimen.Therefore,it is necessary to find an animal model matching with PBC,in order to study the pathogenesis,treatment,and prognosis of PBC.This article introduces the research advances in bile duct ligation models,drug models,antigen models,gene models,and spontaneous models,in order to summarize the features and limitations of the mouse model of PBC in the articles published in recent years and provide a basis for the selection and research of PBC models.关键词
原发性胆汁性胆管炎/疾病模型,动物/综述Key words
primary biliary cholangitis/disease models, animal/review分类
医药卫生引用本文复制引用
张冀豫,范兴良..原发性胆汁性胆管炎小鼠模型的研究进展[J].临床肝胆病杂志,2017,33(11):2235-2238,4.基金项目
上海市卫生和计划生育委员会中医药科研专项课题(2016LP032) （2016LP032）
