临床肝胆病杂志2017，Vol.33Issue(12)：2316-2320,5.DOI:10.3969/j.issn.1001-5256.2017.12.012
蒙药清肝九味散洽疗酒精性肝纤维化的效果观察
Clinical effect of Mongolian medicine Qinggan Jiuwei powder in treatment of alcoholic liver fibrosis
摘要
Abstract
Objective To observe the clinical effect of Mongolian medicine Qinggan Jiuwei powder in the treatment of alcoholic liver fibrosis by observing the improvement in imaging indices. Methods A total of 104 patients with alcoholic liver fibrosis who visited Department of Gastroenterology in Horqin District First People′s Hospital in Tongliao from October 2015 to January 2017 were enrolled and randomly divid-ed into experimental group and control group,with 52 patients in each group. The patients in the experimental group were given Mongolian medicine Qinggan Jiuwei powder,while those in the control group were given reduced glutathione tablets. Liver function parameters,liver -spleen ultrasound findings,and liver stiffness measurement (LSM)determined by FibroScan were observed before and after treatment. The independent samples t - test was used for comparison of normally distributed continuous data between groups,and the paired samples t - test was used for comparison within each group;the Wilcoxon rank sum test was used for comparison of non - normally distributed continuous da-ta between groups. Results Both groups had varying degrees of improvements in clinical symptoms and signs. Both groups had significant changes in alanine aminotransferase,aspartate aminotransferase (AST),gamma - glutamyl transpeptidase (GGT),and LSM after treatment (experimental group:Z = - 3. 09,- 7. 19,and - 8. 27,t = 7. 13,P = 0. 002,< 0. 001,< 0. 001,and < 0. 001;control group:Z = -3. 28,- 4. 60,and - 5. 06,t = 8. 54. P = 0. 001,< 0. 001,< 0. 001,and < 0. 001). There were significant differences in AST and GGT after treatment between the two groups (Z = - 2. 02 and - 2. 15,P = 0. 04 and 0. 03). Both groups had significant changes in oblique di-ameter of the right liver lobe,diameter of the portal vein,blood flow rate of the portal vein,spleen thickness,and diameter of the splenic vein after treatment (experimental group:t = 6. 48,11. 02,2. 20,3. 30 and 5. 30,P < 0. 001,< 0. 001,= 0. 030,< 0. 001,and < 0. 001;control group:t = 3. 51、6. 31、2. 68、3. 06、4. 71,P = 0. 01,< 0. 001,= 0. 01,< 0. 001,and < 0. 001). There were significant differ-ences in oblique diameter of the right liver lobe and diameter of the portal vein after treatment between the two groups (t = 3. 96 and 3. 53, P = 0. 02 and 0. 01). Conclusion Mongolian medicine Qinggan Jiuwei powder has a good clinical effect in the treatment of alcoholic liver fibrosis and can effectively reduce the imaging index LSM and values measured by abdominal color Doppler ultrasound in patients with alco-holic liver fibrosis.关键词
蒙药/肝硬化,酒精性/弹性成像技术Key words
mongolian medicine/liver cirrhosis/alcoholic/elasticity imaging technigues分类
医药卫生引用本文复制引用
戈宏焱,张仕华,赵百岁,于传科..蒙药清肝九味散洽疗酒精性肝纤维化的效果观察[J].临床肝胆病杂志,2017,33(12):2316-2320,5.基金项目
内蒙古自然科学基金面上项目(2015MS0805) （2015MS0805）
