临床肝胆病杂志2017，Vol.33Issue(12)：2457-2461,5.DOI:10.3969/j.issn.1001-5256.2017.12.046
基于非酒精性脂肪性肝病机制及洽疗的动物模型研究进展
Research advances in animal models based on the pathogenesis and treatment of nonalcoholic fatty liver disease
陈艳珍 1陈成良 1田兴 1焦健1
作者信息
- 1. 吉林大学中日联谊医院 消化内科,长春 130033
- 折叠
摘要
Abstract
Nonalcoholic fatty liver disease (NAFLD)is a continuous disease spectrum characterized by the accumulation of excessive lipid in hepatocytes. Simple hepatic steatosis may progress to NAFLD and even liver fibrosis,liver cirrhosis,and finally hepatocellular carcinoma. Animal models can simulate different causes and histopathological and pathophysiological changes in each stage of NAFLD and thus provide critical guidance for understanding the pathogenesis of NAFLD and selecting therapeutic measures. At present,there are still no ideal animal models that can simulate the whole disease spectrum. This article introduces the most frequently used and recently developed animal models for NAFLD and NAFLD - induced liver cancer and summarizes possible therapeutic targets with reference to the experimental pathogenesis of NAFLD in animal models,in order to provide a basis for further research on the pathogenesis and treatment of NAFLD.关键词
非酒精性脂肪性肝病/模型,动物/综述Key words
nonalcoholic fatty liver disease/model animal/review分类
医药卫生引用本文复制引用
陈艳珍,陈成良,田兴,焦健..基于非酒精性脂肪性肝病机制及洽疗的动物模型研究进展[J].临床肝胆病杂志,2017,33(12):2457-2461,5.
