临床神经外科杂志2017，Vol.14Issue(6)：413-416,4.DOI:10.3969/j.issn.1672-7770.2017.06.003
基于SWI检测的大鼠脑微出血后血胱抑素C水平的变化分析
Mechanism analysis of correlation between cystatin C and brain micro hemorrhage in rats based on SWI
韩玉庆 1许阳阳 2董力庆 2赵理乐 2杨新宇1
作者信息
- 1. 300052 天津,天津医科大学总医院神经外科
- 2. 天津市西青医院神经外科
- 折叠
摘要
Abstract
Objective The changes of cystatin C levels in brain hemorrhage of SHR rats were investigated by SWI sequence analysis.Methods 30 SHR rats underwent autologous femoral artery cystatin C blood test and SWI scanning before modeling.15 in the trial group,10μl autologous arterial blood were injected in the brain parenchyma by stereotary and again underwent SWI scanning,15 in the control group were given the same intervention,but without blood injection.Femoral artery blood cystatin C level were analyzed 3 h and 6 h after modeling,and the rats were treated with marrow breaking for brain pathology.Results Before modeling,the level of cystatin C in the observation group was ( 0.08 ±0.03 ) mg/dl.After modeling,the hematoma can be clearly detected by SWI,and it is consistent with the pathological findings.After 3 hours,the level of cystatin C in the observation group was (0.31 ±0.03) mg/dl,and that of the control group was (0.10 ± 0.03) mg/dl.The cystatin C level in the 6 hour observation group was (0.36 ±0.05) mg/dl,and the control group was ( 0.10 ±0.03 ) mg/d.P <0.01.Conclusion Cystatin C level micro hemorrhage in the brain of SHR rats is increased,consistent with the results of SWI and pathological results,can be used as SHR of rat brain microvascular hemorrhage sensitive index.关键词
胱抑素C/脑微出血/SHR大鼠/磁敏感加权成像Key words
cystatin C/cerebral hemorrhage/SHR rats/SWI分类
医药卫生引用本文复制引用
韩玉庆,许阳阳,董力庆,赵理乐,杨新宇..基于SWI检测的大鼠脑微出血后血胱抑素C水平的变化分析[J].临床神经外科杂志,2017,14(6):413-416,4.
