临床输血与检验2017，Vol.19Issue(6)：592-595,4.DOI:10.3969/j.issn.1671-2587.2017.06.018
山莨菪碱注射液联合阿奇霉素序贯治疗支原体肺炎患儿的疗效
A Therapeutic Effect of Anisodamine Combined with Azithromycin Sequential Administration on Children with Mycoplasma Pneumonia
摘要
Abstract
Objective To investigate the clinical efficacy of anisodamine injection combined with azithromycin sequential therapy for the treatment of Mycoplasma pneumonia and its effect on serum inflammatory and immunological markers. Methods Eighty children infected with M. pneumonia in the hospital were randomly divided into two groups from February 2015 to February 2017. The control group was only given azithromycin,the observation group was given anisodamine injection combined with azithromycin sequential therapy. The effective rate of clinical treatment, serum cytokines and immunological indexes,the disappearance of clinical symptoms and signs,and the duration of hospitalization were compared and analyzed. Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The levels of IgA,IgM and IgG in the observation group were significantly higher than those in the control group (P<0.05). MCP-4,MDC,CysLTs,sICAM-1,and IL-17A were found to be decreased significantly in the observation group than those in the control group (P<0.05). The time of cough appearance in the observation group was earlier than that in the control group. The duration of fever,wheezing,lung rales and the hospitalization was shorter than that of the control group (P<0.05). Conclusion The anisodamine injection combined with azithromycin sequential therapy in the treatment of Mycoplasma pneumonia infection may improve the clinical curative effect ,decrease the serum inflammatory cytokines and increase immunological markers,resulting in a prompt reduction of the clinical manifestations.关键词
山莨菪碱注射液/阿奇霉素/支原体肺炎/疗效Key words
Anisodamine injection/Azithromycin/Mycoplasma pneumonia/Therapeutic efficacy分类
医药卫生引用本文复制引用
徐康,李钊,王小象,施益农..山莨菪碱注射液联合阿奇霉素序贯治疗支原体肺炎患儿的疗效[J].临床输血与检验,2017,19(6):592-595,4.基金项目
本课题受江苏省卫生厅科研课题基金支持项目(No. LZ13098)资助 （No. LZ13098）
