国际眼科杂志2017，Vol.17Issue(11)：2060-2064,5.DOI:10.3980/j.issn.1672-5123.2017.11.16
骨髓间充质干细胞在角膜损伤修复中的应用和研究进展
Application and research progress of bone marrow mesenchymal stem cells in corneal injury repair
摘要
Abstract
Bone marrow mesenchymal stem cells (BMSCs) are a class of cells that can differentiate into different kind of corneal cells both in vitro and in vivo,which include corneal epithelial cells,limbal epithelial cells and corneal stromal cells.BMSCs could differentiate into corneal epithelial cells after transplantation,which can not only repair the damaged corneal,but also relieve inflammatory injury caused by the inflammatory cell infiltration.The other function of BMSC transplantation is to reduce the rejection after corneal transplantation by inhibiting cell damage and apoptosis.BMSC can also express a variety of factors on the carrier,these factors paly the important role in promoting the proliferation of limbal stem cells.These findings above provide a new direction for the fundamental study of ophthalmology,and put forward new clinical treatment ideas for corneal disease,both of them have broad protect for development,in this paper,the research status and progress of BMSC in the repair of corneal injury are reviewed.关键词
骨髓间充质干细胞/角膜损伤与修复/研究/应用Key words
bone marrow mesenchymal stem cells/corneal injury repair/research/application引用本文复制引用
董昕,胡竹林..骨髓间充质干细胞在角膜损伤修复中的应用和研究进展[J].国际眼科杂志,2017,17(11):2060-2064,5.基金项目
Yunnan Provincial Applied Basic Research Joint Project of Department of Science and Technology and Kunming Medical University (No.2014FB074)云南省科技厅-昆明医科大学应用基础研究联合专项(No.2014FB074) （No.2014FB074）
