国际眼科杂志2017，Vol.17Issue(11)：2161-2163,3.DOI:10.3980/j.issn.1672-5123.2017.11.43
多种药物联合鼠神经生长因子治疗外伤性视神经挫伤
Clinical efficacy of multiple agents combined with nerve growth factor injection in the treatment of traumatic optic nerve contusion
摘要
Abstract
AIM:To observe the effect of nerve growth factor treatment on traumatic optic nerve contusion and evaluate its therapeutic effect.METHODS:From January 2012 to January 2016,48 cases (50 eyes) with optic nerve contusion were treated.Retrospective study was carried out and the patients were randomly divided into two groups,treatment group 24 cases of 24 eyes,26 eyes of 24 cases in the control group;the treatment group mainly used mouse nerve growth factor injection 30μg,1 times daily intramuscular injection of medication,6wk,with the application of high pressure hyperbaric oxygen therapy,glucocorticoid and vitamin treatment;the treatment of control group was the same as treatment group,but without the injection of mouse nerve growth factor.Visual acuity,visual evoked potential (VEP) and mean sensitivity (MS),and mean deviation (MD) were examined in all patients at 6wk after the treatment.RESULTS:After treated for 6wk,there were significant differences in the best corrected visual acuity (P＜ 0.05)between the two groups.VEP P100 latency of treatment group was 98.76±6.93ms,amplitude was 5.22±1.64μV,those of the control group were 116.52±8.82ms,4.28± 1.75μV,both significantly different between the two groups (P＜0.05).The differences on MS and MD were significant (P＜0.05).CONCLUSION:The treatment of traumatic optic nerve contusion with nerve growth factor injection has more obvious curative effect.关键词
鼠神经生长因子/视神经挫伤/临床疗效Key words
mouse nerve growth factor/optic nerve contusion/clinical curative effect引用本文复制引用
王莉,李鹏,郭雄..多种药物联合鼠神经生长因子治疗外伤性视神经挫伤[J].国际眼科杂志,2017,17(11):2161-2163,3.基金项目
Special Scientific Research Program of Shaanxi Provincial Education Department (No.16JK1665)陕西省教育厅专项科研计划项目(No.16JK1665) （No.16JK1665）
