农药学学报2017，Vol.19Issue(6)：744-754,11.DOI:10.16801/j.issn.1008-7303.2017.0103
阿维菌素B2海藻酸钠-壳聚糖包埋颗粒剂的制备及性能研究
Abamectin B2-loaded alginate-chitosan embedding granules:preparation and characteristics
摘要
Abstract
In order to improve the pesticide utilization rate of the abamectin B2, the abamectin B2-loaded alginate-chitosan embedding granules was prepared by complex coacervation method. Sodium alginate and chitosan were used as composite carriers. The physicochemical properties and release characteristics of embedding granules were studied. Optimization formula was obtained through orthogonal test design. The most important factors of orthogonal test that influence the entrapment efficiency of embedding granules were carried out by single factor tests. The chemical structure of the abamectin B2-loaded embedding granules was characterized by infrared (IR) spectroscopy. The morphology of the embedding granules was examined using scanning electron microscopy (SEM). The soil embedment release assay was employed to explore the release characteristics of the prepared abamectin B2-loaded alginate-chitosan embedding granules. The optimum formula was as follows:1.5%(m/m) of sodium alginate, 1%(m/m) of chitosan, 0.75% (m/m) of Tween-20, the dosage ofm (abamectin B2) :m (alginate) = 1 : 2, and oil to water ratio =1 : 20. The embedding granules prepared under optimum conditions had a drug loading of 22.38% ± 0.25%. And the entrapment efficiency was 95.26% ± 0.61%. Scanning electron microscope images showed that the prepared abamectin B2-loaded embedding granules exhibited Irregular appearance. Infrared spectroscopy data revealed that abamectin B2 was successfully embedded in the carrier. Release property testing of three kinds of embedding granules in soil indicated that serious burst release was observed. The release amount of the abamectin B2 in the first 30 d was higher than 60% of the total release volume in 80 d. And smaller particles had faster release rate. The cumulative release of abamectin B2-loaded alginate-chitosan embedding granules followed a first-order kinetics equation (150-300 μm and > 300 μm) and the Higuchi equation (150-300μm and < 150 μm).关键词
复凝聚法/阿维菌素B2/包埋颗粒剂/正交试验/土壤包埋释放法Key words
complex coacervation method/abamectin B2/embedding granule/orthogonal test/the soil embedment release assay分类
农业科技引用本文复制引用
王召,尹明明,陈福良..阿维菌素B2海藻酸钠-壳聚糖包埋颗粒剂的制备及性能研究[J].农药学学报,2017,19(6):744-754,11.基金项目
国家重点研发计划项目(2016YFD0200500). （2016YFD0200500）
