山东医药2017，Vol.57Issue(45)：28-30,3.DOI:10.3969/j.issn.1002-266X.2017.45.008
GDM孕妇肘静脉及新生儿脐静脉血清中AGE、RAGE水平变化及意义
Changes and significance of AGE and RAGE in venous and umbilical vein serum of pregnant women with GDM
摘要
Abstract
Objective To investigate the changes in levels of advanced glycation end products (AGE)and its recep-tor (RAGE)in the venous and umbilical vein serum of pregnant women with gestational diabetes mellitus (GDM),and its relationships with the onset of GDM and the development of early neonatal nervous system. Methods Eighty cases of GDM pregnant women (group GDM)were selected,and 80 cases of pregnant women with normal glucose tolerance in the same period of hospital delivery and the same gestational age were selected as the control group. The levels of AGE and RAGE in the maternal and neonatal umbilical vein serum were detected by ELISA in two groups. The neonatal behavioral neurological assessment (NBNA)scores were measured at 72 h after neonatal birth. The correlation between these indexes was analyzed. Results The levels of AGE and RAGE in the maternal serum and neonatal umbilical vein serum of the GDM group were higher than those in the control group (all P < 0. 05). The neonatal active muscle tension,primitive re-flex,and NBNA total score were higher in the GDM group than in the control group (all P < 0. 05). The levels of AGE and RAGE in the maternal serum of the GDM group were positively correlated with AGE and RAGE levels in the umbilical vein serum of neonates (r = 0. 725,0. 473;both P < 0. 05). The levels of AGE and RAGE in the maternal serum of the GDM group were negatively correlated with NBNA score (r = - 0. 415,- 0. 320;both P < 0. 05). The levels of AGE and RAGE in the neonatal umbilical vein serum of the GDM group were negatively correlated with NBNA score (r = - 0. 294,- 0. 280;both P < 0. 05). Conclusion The levels of AGE and RAGE in the GDM maternal vein serum and neonatal um-bilical vein serum increase,which are related to the occurrence of GDM and the early neurological deficits of newborns.关键词
妊娠期糖尿病/晚期糖基化终末产物/糖基化终末产物受体/新生儿神经行为测定评分/新生儿Key words
gestational diabetes mellitus/advanced glycation end products/receptor for advanced glycation end prod-ucts/neonatal behavioral neurological assessment score/neonatal分类
医药卫生引用本文复制引用
邵婷,邢军,周剑利,曹佳宇,赵秀兰..GDM孕妇肘静脉及新生儿脐静脉血清中AGE、RAGE水平变化及意义[J].山东医药,2017,57(45):28-30,3.基金项目
河北省医学适用跟踪项目计划(GL201646). （GL201646）
