生物技术通报2017，Vol.33Issue(11)：35-40,6.DOI:10.13560/j.cnki.biotech.bull.1985.2017-0455
RNAi技术的最新研究进展
Latest Research Progress on RNA Interference Technology
摘要
Abstract
RNA interference (RNAi) is a phenomenon in which the target gene is silenced by double-stranded RNA (dsRNA)inducing homologous mRNA degradation in the eukaryotic cells.At present,RNAi technology,as an effective tool for gene regulation,is widely used in pest control,cure of tumor and cancer duo to its high specificity,high efficiency,transmission and other characteristics.Especially in the medical application,compared with the traditional vaccine prevention and drug therapy,RNAi technology has unparalleled advantages of target medication,reducing side effects and inhibiting the expression of virulence genes,thus it plays an increasing significant role in the new treatment methods of cancer and other diseases.The mechanism,introducing methods of RNAi and its latest application in plant improvement,biological control,insect resistance,disease prevention and treatment are synthetically analyzed and evaluated in this paper,for providing the reference for researchers in related fields.关键词
RNAi/dsRNA/shRNA/转基因法/作用机理Key words
RNAi/dsRNA/shRNA/transgenic method/action mechanism引用本文复制引用
王伟伟,刘妮,陆沁,凌晓霏,陈航..RNAi技术的最新研究进展[J].生物技术通报,2017,33(11):35-40,6.基金项目
国家林业局948项目(2014-4-66),中央级公益性科研院基本科研业务费专项(CAFYBB2014ZD005) （2014-4-66）
