生物技术通报2017，Vol.33Issue(11)：48-53,6.DOI:10.13560/j.cnki.biotech.bull.1985.2017-0301
核酸适配子结合无机纳米材料在肿瘤研究中的应用
Application of Aptamers Conjugated Inorganic Nanomaterial in Tumor Research
摘要
Abstract
At nowadays in the promotion of precise medical treatment,how to achieve tumor targeted therapy and reduce the side-effects of radiotherapy is particularly critical after we understood the mechanism of the key molecular targets closely related to tumorigenesis.Aptamers are single-stranded DNA or RNA oligonucleotides which can bind with various targets at high affinity and specificity.Inorganic nanomaterial is an important part of nanomaterial as a medical diagnosis and treatment preparation.Taking the advantage of the properties of aptamers binding with their targets at high affinity,the system of their binding with inorganic nanomaterial can be applied in the tumor research in an integrated approach of targeted binding,biological imaging and drug delivery,concurrently which efficiently promotes the development of nucleic acid nanotechnology.In this review,we discuss the application of varied inorganic nanomaterial binding with the aptamers in tumor research and the safety of inorganic nanomaterial in medical applications,aiming at earlier achieving the development of new targeted therapy strategies to tumor.关键词
核酸适配子/纳米材料/肿瘤Key words
aptamers/nanomaterial/tumor引用本文复制引用
彭立,张兴梅..核酸适配子结合无机纳米材料在肿瘤研究中的应用[J].生物技术通报,2017,33(11):48-53,6.基金项目
国家自然科学基金项目(81272509,81471388),广东省自然科学基金项目(2014A030313351) （81272509,81471388）
