山西医科大学学报2017，Vol.48Issue(12)：1284-1287,4.DOI:10.13753/j.issn.1007-6611.2017.12.018
难治性和一般性抑郁症患者情绪面孔加工的认知偏见对比研究
Comparative study on the cognitive bias of facial expressions of emotion between treatment-resistant and non-treatment-resis-tant depression patients
朱敏 1李潇 2罗静 3鲁晓波 1苏掌权 1翟歆明1
作者信息
- 1. 陕西省宝鸡市康复医院心身科,宝鸡 721001
- 2. 宝鸡市中心医院
- 3. 宝鸡市中医医院
- 折叠
摘要
Abstract
Objective To explore the difference of cognitive bias of emotional facial expressions between treatment-resistant and non-treatment-resistant depression patients. Methods Using visual emotional oddball paradigm(i. e. making judgments about happy and sad faces)to manipulate the processing of emotional information,the event-related potential N170 component(i. e. the negative wave component occurs around 170 ms)was tested in 28 cases of treatment-resistant depression(TRD group),32 cases of non-treatment-re-sistant depression(NTRD group),and 28 healthy subjects(control group). Results ①Compared with control group,the N170 am-plitudes for happy and neutral faces were decreased in both TRD group and NTRD group(P < 0. 05),N170 amplitudes for sad faces were increased in TRD group(P < 0. 05),but no significant difference of N170 amplitudes for sad faces was found in NTRD group(P> 0. 05). Compared with TRD group,the N170 amplitudes for happy faces were increased,while N170 amplitudes for sad faces were decreased in NTRD group(P < 0. 05). A positive relationship was observed between N170 amplitude and the Hamilton depression rat-ing scale(HDRS)score for sad faces identification in two depression groups(P < 0. 05). Conclusion The treatment-resistant depres-sion patients present the mood-brightening effect with cognitive bias on negative emotional processing. It further suggests that the un-conscious negative cognitive bias of treatment-resistant depression patients may be a potential biomarker for the clinical adjunctive the-rapy.关键词
难治性抑郁症/情绪面孔加工/认知偏见/事件相关电位/N170Key words
treatment-resistant depression/emotional facial processing/cognitive bias/event-related potential/N170分类
医药卫生引用本文复制引用
朱敏,李潇,罗静,鲁晓波,苏掌权,翟歆明..难治性和一般性抑郁症患者情绪面孔加工的认知偏见对比研究[J].山西医科大学学报,2017,48(12):1284-1287,4.
