现代检验医学杂志2017，Vol.32Issue(6)：71-73,3.DOI:10.3969/j.issn.1671-7414.2017.06.020
骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析
Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients
唐元艳 1张利铭 1张江召 1熊涛 1梁艳 1余卓君 1刘荟敏 1刘敏 1黄知平1
作者信息
- 1. 华中科技大学同济医学院附属荆州医院血液内科,湖北荆州 434020
- 折叠
摘要
Abstract
Objective To investigate the correlation between morphological abnormalities and abnormal myelodysplastic syn-dromes(MDS)cloning.Methods 82 cases of MDS were collected with complete FISH and morphological abnormalities. The relationship between MDS cell morphology and chromosome abnormality was investigated.Results 45 cases of chromo-somal abnormalities were found,and +8 were the most frequent chromosomal abnormalities.8 cases were +8,-5 and 5q-were 6,20q-were 7,-7 and 7q-were 5,complex karyotypes(>3 abnormalities)were 6.There were statistically significant differences in the proportion of primordial cells,megakaryocyte dysplasia,megakaryocyte abnormalities between karyotype abnormal group and karyotype normal group(P<0.05).There were statistically significant differences in the proportion of abnormal karyotype among high risk group and low risk group,the low risk group and medium risk group(P<0.05).Con-clusion The chromosomal abnormalities of MDS patients would be related to morphological changes.关键词
骨髓增生异常综合征/发育异常/荧光原味杂交Key words
myelodysplastic syndrome/dysplasia/fluorescence in situ hybridization分类
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唐元艳,张利铭,张江召,熊涛,梁艳,余卓君,刘荟敏,刘敏,黄知平..骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析[J].现代检验医学杂志,2017,32(6):71-73,3.
