陕西医学杂志2017，Vol.46Issue(12)：1718-1721,4.DOI:10.3969/j.issn.1000-7377.2017.12.044
动态增强MRI用于新辅助放化疗食管癌患者的治疗反应研究
The Study of Dynamic contrast-enhanced MRI for treatment response assessment in patients with oesophageal cancer receiving neoadjuvant chemoradiotherapy
摘要
Abstract
To explore and evaluate the potential value of dynamic contrast-enhanced (DCE) magnetic reso-nance imaging (MRI) for the prediction of pathologic response to neoadjuvant chemoradiotherapy (nCRT) in oesoph-ageal cancer .Methods :Twenty-seven patients underwent DCE -MRI before ,during (week 2-3) and after nCRT , but before surgery (pre/per/post ,respectively) .Histopathologic tumour regression grade (TRG) was assessed af-ter oesophagectomy .Tumour area-under -the -concentration time curve (AUC) ,time -to -peak (TTP) and slope were calculated .The ability of these DCE -parameters to distinguish good responders (GR ,TRG 1-2) from poor responders (noGR ,TRG P 3) ,and pathologic complete responders (pCR) from no-pCR was assessed .Re-sults :Thirteen patients (48 .1% ) showed GR of which eight patients (33 .3% ) pCR .Analysis of AUC change throughout treatment ,AUCper-pre ,was most predictive for GR ,at a threshold of 22 .7% resulting in a sensitivity of 92% ,specificity of 77% ,PPV of 79% ,and a NPV of 91% .AUCpost-pre was most predictive for pCR ,at a threshold of-24 .6% resulting in a sensitivity of 83% ,specificity of 88% ,PPV of 71% ,and a NPV of 93% .TTP and slope were not associated with pathologic response .Conclusions :This study demonstrates that changes in AUC throughout treatment are promising for prediction of histopathologic response to nCRT for oesophageal cancer .关键词
食管肿瘤/放射性核素成像/磁共振成像/化学放射疗法,辅助Key words
Esophageal Neoplasms/radionuclide imaging/Magnetic resonance imaging/Chemoradiothera-py,adjuvant分类
医药卫生引用本文复制引用
张泉,陈力,张辉,吴建,彭进,柏根基,王浩..动态增强MRI用于新辅助放化疗食管癌患者的治疗反应研究[J].陕西医学杂志,2017,46(12):1718-1721,4.基金项目
南京医科大学科技发展基金资助项目(2011NJMU239) （2011NJMU239）
