实用医学杂志2017，Vol.33Issue(21)：3511-3513,3.DOI:10.3969/j.issn.1006-5725.2017.21.004
血肌酐联合胱抑素C根据KDIGO标准诊断急性肾损伤
Combined criteria of both serum cystatin c and creatinine for acute kidney injury based on KDIGO and its clinical implications
摘要
Abstract
Objective We aimed to investigate the clinical values of combination of blood creatinine and cystatin C for acute kidney injury(AKI)diagnosi. Methods Total 7 627 patients were studied retrospectively. The AKI was classified by creatinine or cystatin C according to the Kidney Disease:Improving Global Outcomes criteria. Results The maximum levels of cystatin C and creatinine were correlated(Spearman′s rank coefficient 0.699,P < 0.001). The area under a receiver operating characteristic curve of maximum cystatin C value for pre-dicting in-hospital death was 0.761(95% confidence interval 0.693 ~ 0.828). Total 1 004 and 173 patients were classified into AKI by blood creatinine or by cystatin C(13.2% vs.2.3%,P<0.001),respectively.The total inci-dence of AKI was 14.7% diagnosed by the combination of the two markers.In multivariable logistic model,the cre-atinine negative plus cystatin C positive group was associated with a higher in-hospital death compared with the cre-atinine and cystatin C double negative group(OR 15.524,95% confidence interval 5.110 ~ 47.166,P < 0.001). Conclusion Combination of cystatin C increased sensitivity of creatinine for AKI diagnosis and facilitated to iden-tify in-hospital patients with high risk.关键词
急性肾损伤/胱抑素C/住院死亡/全球肾脏病预后组织/诊断Key words
acute kidney injury/cystatin C/in-hospital death/kidney disease: improving global outcomes/diagnosis引用本文复制引用
张裕生,陈源汉,陈诗歆,李志莲,吴燕华,梁馨苓..血肌酐联合胱抑素C根据KDIGO标准诊断急性肾损伤[J].实用医学杂志,2017,33(21):3511-3513,3.基金项目
广东省科技计划协同创新与平台环境建设项目(编号:2017A070709008) （编号:2017A070709008）
广州市科技计划项目产学研协同创新重大专项(编号:201604020037) （编号:201604020037）
广东省卫生计生适宜技术推广项目资助项目(编号:2016200) （编号:2016200）
