实用医学杂志2017，Vol.33Issue(21)：3589-3592,4.DOI:10.3969/j.issn.1006-5725.2017.21.023
轻度急性高容量血液稀释对老年患者术后早期认知功能的影响
Effects of light acute hypervolemic hemodilution on early postoperative cognitive function in elderly patients
摘要
Abstract
Objective To investigate the effects of light acute hypervolemic hemodilution on early postop-erative cognitive function in elderly patients. Methods A total of 60 patients treated by radical surgery were equally randomized to an AHH and a non-AHH control group.Using the Mini-Mental State Examination scale (MMSE),we evaluated the cognitive function of the patients.We made comparisons between the two groups in the plasma S100β levels at T0(before anesthesia induction),T1(immediately after hemodilution),T2(immediately after operating),T(36 hour after operating)and T(424 hour after operating).Results The S-100β lever at T2、T3 and T4were markedly higher than T0in both groups(P<0.05);At T3and T4,the S-100β lever was higher in non-AHH control group than AHH group(P<0.05).There was no significant difference in the incidence of postopera-tive cognitive dysfunction between the two groups(P>0.05)There was no significant difference in the incidence of postoperative cognitive dysfunction between the two groups(P > 0.05). Conclusions AHH can significantly reduce plasma S100β in elderly patients,but there is no effect on early postoperative cognitive function.关键词
急性高容量血液稀释/术后早期认知功能/老年患者Key words
acute hypervolemic hemodilution/elderly/cognitive function引用本文复制引用
陈汉文,邢祖民,刘晓磊,张艳静,李集源,陈志强,周翠云,张奕文..轻度急性高容量血液稀释对老年患者术后早期认知功能的影响[J].实用医学杂志,2017,33(21):3589-3592,4.基金项目
广东省医学科学技术研究基金(编号:B2012344) （编号:B2012344）
佛山市十三五重点专科资助项目(编号:FSZDZK135049) （编号:FSZDZK135049）
佛山市医学类科技攻关项目(编号:2015AB002483) （编号:2015AB002483）
