天津中医药2017，Vol.34Issue(12)：802-805,4.DOI:10.11656/j.issn.1672-1519.2017.12.04
柴胡疏肝散加减方治疗肠易激综合征随机对照临床研究的Meta分析
A Meta-analysis of randomized controlled clinical study on treating irritable bowel syndrome with modified Chaihu Shugan powder
摘要
Abstract
[Objective] To evaluate the clinical efficacy and safety of Chaihu Shugan powder in the treatment of irritable bowel syndrome (IBS). [Methods] CNKI, CBM, VIP and Wanfang data, PubMed, The Cochrane Library, Embase were searched for the randomized controlled clinical trials of all Chaihu Shugan powder in the treatment of irritable bowel syndrome, and the time was set from the time when the database was created to October 10, 2016. Meta-analysis was carried out by RevMan 5.3 software, which was used to evaluate the quality of the method and extract valid data. [Results] Eleven studies were eventually included and included a total of 1288 patients. Meta-analysis showed that Chaihu Shugan powder could significantly improve the total effective rate, markedly effective rate and cure rate in IBS, compared with conventional Western medicine treatment. Total effective rate[OR=4.98, 95%CI(3.56, 6.96), P<0.00001], cure rate [OR=2.19,95%CI (1.49,3.20), P<0.0001], significantly effective rate [OR=1.84, 95%CI (1.40, 2.41), P<0.0001]. And no significant reactions were found. [Conclusion] Chaihu Shugan powder has better clinical efficacy than routine Western medicine in the treatment of irritable bowel syndrome. However, considering that the quality of the literatures is low, there may be a high risk of bias. So more designs contain a large sample of clinical trials are needed in the hope that we can provide a more reliable clinical evidence-based medicine.关键词
柴胡疏肝散/肠易激综合征/随机对照试验/Meta分析Key words
Chaihu Shugan powder/irritable bowel syndrome/randomized controlled trial/Meta-analysis分类
医药卫生引用本文复制引用
苏凯奇,沈艳婷,林柳兵,阙任烨,陈懿榕,李勇..柴胡疏肝散加减方治疗肠易激综合征随机对照临床研究的Meta分析[J].天津中医药,2017,34(12):802-805,4.基金项目
国家自然科学基金项目(81573775) （81573775）
上海市卫生系统百人计划基金项目(XBR2013120) （XBR2013120）
第二批上海市卫生系统学科带头人和优秀青年人才培养计划基金资助项目(沪卫计委科教 [2013]9号-50) （沪卫计委科教 [2013]9号-50）
上海市科学技术委员会项目(15401930700). （15401930700）
