应用化学2017，Vol.34Issue(12)：1457-1461,5.DOI:10.11944/j.issn.1000-0518.2017.12.170311
基于香豆素的比率型次氯酸荧光探针
A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite
摘要
Abstract
Hypochlorous acid ( HClO ) is one of the biologically important reactive oxygen species ( ROS ) , which plays important roles in the human immune defence system, and contributes to the destruction of invading bacteria and pathogens.Here, a novel ratiometric probe for detection of hypochlorite was designed and developed based on the coumarin.The sensor shows excellent selectivity, high sensitivity(12 nmol/L) and a rapid response ( within 5 s ) toward hypochlorite, accompanied with an obvious color change from colorless to yellow. Other anions and ROS all triggers very minor changes. Furthermore, the sensing mechanism was confirmed by electrospray ionization-mass spectrometry(ESI-MS) and spectrometry analysis, which was based on the strong oxidized by HClO/ClO-, then hydrolyzed to generate fluorescent compound.关键词
香豆素/次氯酸/荧光探针/快速响应Key words
coumarin/hypochlorite/fluorescence probe/fast response分类
化学化工引用本文复制引用
张伟杰,霍方俊,阴彩霞..基于香豆素的比率型次氯酸荧光探针[J].应用化学,2017,34(12):1457-1461,5.基金项目
国家自然科学基金(21672131,21775096,21705102)、山西省人才支持计划(2014401)、山西省归国基金(2017-026)资助 Supported by the National Natural Science Foundation of China(No.21672131, No.21775096, No.201705105), the Talents Support Program of Shanxi Province(No.2014404), the Shanxi Province Foundation for Returnee(No.2012-007) （21672131,21775096,21705102）
