中风与神经疾病杂志2017，Vol.34Issue(11)：997-1002,6.
R2*值在不同运动障碍亚型原发性帕金森病 异质性的研究价值
The R2* value quantitative study on different movement disorder subtypes of Idiopathic Parkinson' s disease
摘要
Abstract
Objective To investigate the diagnostic value of R 2* value on different subtypes of IPD according to motor symptoms.Methods 122 patients with IPD were divided into tremor-dominant PD(n=61),mixed subtype PD(n=33),postural instability and gait disorder (PIGD)-dominant PD(n=28).All patients and control subjects were performed ESWAN sequence .R2* value was measured and stasistically analyzed .Results The amended Hoehn-Yahr stage of PIGD-dominant PD was significantly higher than that of the tremor-dominant PD (P<0.01),while the score of Mini-Mental State Examination(MMSE) was significantly lower in the former(P<0.05).No statistical difference was found in age, gender,course of disease and onset side between different subtypes of PD (P>0.05).In control subjects,the R2*value of globus pallidus(GP) was the highest,followed by substantia nigra pars reticulate (SNr) and red nucleus(RN).The lowest R2* value was seen in frontal white matter ( FWM ) .R2* value decreased significantly in substantia nigra pars compacta (SNc),SNr,RN and GP of PIGD-dominant PD compared with control subjects (P<0.05),and decreased in RN and SNc of PIGD-dominant PD compared with tremor-dominant PD(P<0.05),and decreased in RN,SNr,SNc,putamen(PUT),GP and thalamus(THA) of PIGD-dominant PD compared with mixed subtype PD (P<0.05).R2*value decreased in SNr and PUT of tremor-dominant PD compared with mixed subtype PD (P<0.05).Conclusion There is significant difference in clinic symptom between tremor-dominant PD and PIGD-dominant PD .The sites of pathologic brain iron deposition were het-erogeneity in different movement disorder subtypes of PD .The R2* value may help diagnose IPD and distinguish different movement disorder subtypes of IPD .关键词
帕金森病/运动障碍亚型/异质性/脑铁沉积Key words
Parkinson' s disease/Movement disorder subtypes/Heterogeneity/Brain iron deposition分类
医药卫生引用本文复制引用
王波,芮茂萍,陈渝晖,陈婧,张宏江,代红樱,龚霞蓉..R2*值在不同运动障碍亚型原发性帕金森病 异质性的研究价值[J].中风与神经疾病杂志,2017,34(11):997-1002,6.基金项目
云南省应用基础研究(昆医联合专项)项目[2017FE468(-128)] （昆医联合专项）
云南省科技计划项目-王陇德院士工作站(2013IC041),云南省卫生内设研究机构项目(2014NS268,2016NS220) （2013IC041）
