中国病理生理杂志2017，Vol.33Issue(12)：2287-2292,6.DOI:10.3969/j.issn.1000-4718.2017.12.029
白血病细胞源外泌体的作用研究进展
Progress on role of exosomes derived from leukemia cells
摘要
Abstract
Exosomes are bilayer-lipid membrane nanovesicle from almost all living cell types which are in-volved in intercellular substance transporting and signaling communication .Exosomes are 30 ~120 nm in diameter , can transfer bioactive molecules including DNA , RNA, microRNA, protein as well as lipids derived from parents ' cells to re-cipient cells by body fluids , and specifically influence their physiological or pathological conditions .Leukemia is due to malignant proliferation of hematopoietic stem and progenitor cells .It was reported that leukemia cells derived exosomes play a key role in disease progression , drug resistance , and predict prognosis .This paper will outline the role of exosomes de-rived from leukemia cells and provide important information to help explore the molecular pathogenesis , biomarker as well as therapeutic target of leukemia .关键词
白血病细胞/外泌体/生物学功能/分子机制Key words
Leukemia cells/Exosomes/Biological functions/Molecular mechanism分类
医药卫生引用本文复制引用
张娟娟,李瑞玮,贺继刚,欧阳红梅,撒亚莲..白血病细胞源外泌体的作用研究进展[J].中国病理生理杂志,2017,33(12):2287-2292,6.基金项目
国家自然科学基金资助项目( No.31460298 （）
No.81460073 ) （）
云南省科技厅-昆明医科大学联合专项应用基础研究项目(No.2014FB092 （）
No.2014FB099) （）
云南省卫生厅内设机构资助项目(No.2017NS228) （No.2017NS228）
