中国当代儿科杂志2017，Vol.19Issue(12)：1234-1238,5.DOI:10.7499/j.issn.1008-8830.2017.12.002
儿童急性淋巴细胞白血病化疗后合并肺部感染的临床特征
Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy
摘要
Abstract
Objective To examine the clinical features of children with acute lymphoblastic leukemia (ALL) complicated by pulmonary infection after chemotherapy. Methods The clinical data of 108 ALL children (115 case-times) with post-chemotherapy pulmonary infection were retrospectively reviewed. The risk factors for pulmonary infection and the relationship between pathogens and chest CT findings were evaluated. Results The highest incidence (77.4% ) of pulmonary infection occurred during remission induction, peaking at 31-60 days after chemotherapy. Patients with neutropenia had the highest incidence rate of pulmonary infection (67.0%). Bacteria (36%) and fungi (41%) were the two most common pathogens in the 41 patients who were etiologically suspected of or diagnosed with pulmonary infection. There was no significant difference in chest CT findings between patients with bacterial and fungal infections. Conclusions The children with ALL are most susceptible to pulmonary infection during remission induction, especially when they are neutropenic. Bacteria and fungi are the main pathogens of pulmonary infections in these patients. However, the changes in chest CT images are poor indicators of the nature of pulmonary infection.关键词
急性淋巴细胞白血病/肺部感染/儿童Key words
Acute lymphoblastic leukemia/Pulmonary infection/Child引用本文复制引用
张培芬,冯晓勤,吴翠玲,张玉明..儿童急性淋巴细胞白血病化疗后合并肺部感染的临床特征[J].中国当代儿科杂志,2017,19(12):1234-1238,5.基金项目
国家自然科学基金(81270632). （81270632）
