中国临床药理学杂志2017，Vol.33Issue(19)：1865-1867,3.DOI:10.13699/j.cnki.1001-6821.2017.19.004
尼莫地平注射液联合参附注射液治疗创伤性蛛网膜下腔出血的临床研究
Clinical trial of nimodipine injection combined with Shenfu injection in the treatment of traumatic subarachnoid hemorrhage
摘要
Abstract
Objective To observe the clinical effect of nimodipine combined with Shenfu injection in the treatment of traumatic subarachnoid hemorrhage.Methods Eighty-four cases of traumatic subarachnoid hemorrhage patients were randomized divided into control group and treatment group,42 cases in each group.Control group was intravenous drip nimodipine injection 20 mg,qd.Treatment group was intravenous drip Shenfu injection 30 mL,with 5％ glucose injection 250 mL,bid.All patients were treated for 14 d.Clinical effect,levels of inflammation,blood coagulation function and adverse drug reactions were compared in two groups.Results After treatment,good prognosis rates in treatment group and control group were 69.05％ (29/42 cases),47.62％ (20/42 cases),with significant difference (P ＜0.05).The levels of interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),prothrombin time,partial thromboplastin time in treatment group were (0.85 ± 0.11) μg · L-1,(0.57±0.07) μg · L-1,(12.40 ± 1.66) s,(33.75 ± 3.88) s,had significant difference with those in control group,which were (1.06 ± 0.15)μg · L-1,(1.06 ± 0.13)μg · L-1,(14.69 ± 1.63) s,(36.69 ± 4.44) s (all P ＜ 0.05).There were 4 cases of cerebral infarction,2 cases of hydrocephalus,6 cases of cerebral hemorrhage,6 cases of cerebral vasospasm in control group,with the incidence of 42.86％ (18/42 cases).There were 1 case of cerebral infarction,1 case of hydrocephalus,2 cases of cerebral hemorrhage,2 cases of cerebral vasospasm,with the incidence of 14.28％ (6/42 cases).The incidence of adverse drug reactions had significant difference in two groups(P ＜ 0.05).Conclusion The clinical effect of nimodipine combined with Shenfu injection in the treatment of traumatic subarachnoid hemorrhage is great,can benefit the patients' prognosis,improve the inflammation and coagulation function.关键词
尼莫地平注射液/参附注射液/创伤性蛛网膜下腔出血Key words
nimodipine injection/Shenfu injection/traumatic subarachnoid hemorrhage分类
医药卫生引用本文复制引用
沈佳,陈彬,郑关荣..尼莫地平注射液联合参附注射液治疗创伤性蛛网膜下腔出血的临床研究[J].中国临床药理学杂志,2017,33(19):1865-1867,3.基金项目
浙江省医药卫生计划基金资助项目(2011KBY132) （2011KBY132）
