中国临床药理学杂志2017，Vol.33Issue(19)：1871-1873,3.DOI:10.13699/j.cnki.1001-6821.2017.19.006
厄贝沙坦片联合精蛋白生物合成人胰岛素注射液治疗老年2型糖尿病肾病的临床研究
Clinical trial of irbesartan tablets combined with isophane protamine biosynthetic human insulin injection in the treatment of elderly type 2 diabetic nephropathy
摘要
Abstract
Objective To observe the clinical efficacy and safety of irbesartan tablets combined with isophane protamine biosynthetic human insulin injection in the treatment of elderly type 2 diabetic nephropathy.Methods A total of 100 elderly patients with type 2 diabetic nephropathy were randomly divided into control group and treatment group with 50 cases per group.Control group was treated with progesterone biosynthesis human insulin 0.25 U · kg-1 · d-1,bid,subcutaneous injection before breakfast and dinner.Treatment group was orally given irbesartan 150 mg,qd,on the basis of control group.Two groups were treated for 3 months.The clinical efficacy,levels of blood urea nitrogen (BUN),serum creatinine (SCr),24 h urinary albumin excretion rate (24 h UAER),and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 94.00％ (47/50 cases) and 76.00％ (38/50 cases) with statistically significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:BUN were (6.84 ± 0.56),(7.67 ± 0.70) mmol · L-1;SCr were (76.49 ± 8.05),(86.39 ± 8.04) μmol · L-1;24 h UAER were (68.02 ± 6.75),(78.70 ± 7.52) mg · 24 h-1,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in two groups headache,dizziness,palpitations and cough.The incidences of adverse drug reactions in treatment and control groups were 16.00％ and 22.00％ without significant difference (P ＞ 0.05).Conclusion Irbesartan tablet combined with isophane protamine biosynthetic human insulin injection has a definitive clinical efficacy in the treatment of elderly type 2 diabetic nephropathy,which can improve the patients' renal function,without increasing the incidence of adverse drug reactions.关键词
厄贝沙坦片/精蛋白生物合成人胰岛素注射液/2型糖尿病肾病/安全性Key words
irbesartan tablet/isophane protamine biosynthetic human insulin injection/type 2 diabetic nephropathy/safety分类
医药卫生引用本文复制引用
金晓倩,任中杰..厄贝沙坦片联合精蛋白生物合成人胰岛素注射液治疗老年2型糖尿病肾病的临床研究[J].中国临床药理学杂志,2017,33(19):1871-1873,3.基金项目
浙江省医药卫生计划基金资助项目(2011ZHA003) （2011ZHA003）
