中国临床药理学杂志2017，Vol.33Issue(19)：1889-1892,4.DOI:10.13699/j.cnki.1001-6821.2017.19.011
小凹蛋白-1和Ki-67在食管鳞癌中的表达及临床意义
Expressions of Caveolin-1 and Ki-67 in esophageal squamous cell carcinoma tissues and its clinical significance
摘要
Abstract
Objective To explore the expressions of Caveolin-1 and Ki-67 in esophageal squamous cell carcinoma tissues and discuss the clinical significances.Methods The expressions of Caveolin-1 and Ki-67 in 110 specimens of esophageal squamous cell carcinoma tissues (treatment group) and 15 specimens of normal esophageal tissues (control group) were detected by immunohistochemistry technique.The correlation between their positive expression and the elinieopathologie features were analyzed.Results The positive rates of Caveolin-1 were 47.62％ (10/21 cases),70.91％ (39/55 cases),94.11％ (32/34 cases) in low,middle,and high differentiation in treatment group,had significant difference with that in control group,which was 33.33％ (5/15 cases,P ＜ 0.05).The positive rates of Ki-67 were 52.38％ (11/21 cases),85.45％ (47/55 cases),97.06％ (33/34 cases) in low,middle,and high differentiation in treatment group,had significant difference with that in control group,which was 20.00％ (3/15 cases,P ＜0.05).Expression of Caveolin-1 was positively related with expression of Ki-67 in esophageal squamous cell carcinoma tissues(r =0.545,P ＜ 0.001).The positive expression of Caveolin-1 and Ki-67 were correlated with differentiation degree,tumor-node-metastasis (TNM) stage,lymph node metastasis,and liver metastasis(all P ＜0.05).Conclusions The expression levels of Caveolin-1 and Ki-67 are high in esophageal squamous cell carcinoma tissues,which have correlation with differentiation degree,TNM stage,lymph node metastasis,and liver metastasis.关键词
食管鳞癌/小凹蛋白-1/增殖抗原/免疫组化Key words
esophageal squamous cell carcinoma/Caveolin-1/proliferating antigen/immunohistochemistry分类
医药卫生引用本文复制引用
范玉宏,周海丰,侯占富,武雪亮,王立坤,侯雅雄..小凹蛋白-1和Ki-67在食管鳞癌中的表达及临床意义[J].中国临床药理学杂志,2017,33(19):1889-1892,4.基金项目
河北省卫计委医学科学研究重点课题计划基金资助项目(20170791) （20170791）
