中国临床药理学杂志2017，Vol.33Issue(19)：1909-1911,3.DOI:10.13699/j.cnki.1001-6821.2017.19.017
细胞色素P450 2C19基因多态性对氯吡格雷抗血小板作用的影响
Effect of cytochrome P450 2C19 gene polymorphism on clopidogrel antiplatelet therapy
马辉 1吕慧怡 1于晓杰 2胡增春 3孙丽晶 1程荔春 1张策1
作者信息
- 1. 大连医科大学附属第二医院药学部,辽宁大连116027
- 2. 大连医科大学附属第一医院药剂科,辽宁 大连116027
- 3. 大连医科大学附属第二医院神经外科,辽宁大连116027
- 折叠
摘要
Abstract
Objective To investigate the effect of cytochrome P450 2C19 (CYP2C19) gene polymorphism on the antiplatelet therapy of clopidogrel in patients who underwent percutaneous coronary intervention (PCI).Methods Fifty-five patients who underwent PCI,as well as twenty-three healthy subjects,were enrolled in this study.The genotypes of the samples were identified by gene chips hybridization.The contents of soluble P-selectin (CD62p) and platelet glycoprotein GP Ⅱ b/Ⅲ a fibrinogen receptor(PAC-1) in patients who underwent PCI were detected by flow cytometry (FCM).The expressions of platelet activation markers were calculated according to interquartile range method.Results Seven patients with CYP2C19 * 2/* 2 genotypes were poor metabolizers,while twenty-eight patients with CYP2C19 * 1/* 2,CYP2C19 * 1/ * 3 were intermediate metabolizers,twenty patients with CYP2C19 * 1/ * 1 were extensive metabolizers.In intermediate metabolism (* 1/* 2),intermediate metabolism (* 1/* 3) and poor metabolism group,the CD62p expressions were (6.73 ± 5.69) ％,(10.94 ± 9.80) ％,(14.35 ± 6.24) ％,(16.80 ± 13.65) ％,respectively,statistically significant differences were found when compared with the control group;The PAC-1 expressions were (1.06 ± 0.69) ％,(2.10 ± 4.09) ％,(2.37 ± 3.15) ％,(2.89 ± 2.75) ％,and there were significant differences in CD62p and PAC-1 among the groups(P ＜0.05).The genotypes of extensive metabolism was high in the response to clopidogrel,while those of intermediate metabolism were moderate and poor metabolism were low.Conclusion Intermediate metabolism genotype patients could be adjusted to the dose of clopidogrel or the use of other antiplatelet drugs,and the poor metabolism genotype patients should be used other antiplatelet drugs.关键词
基因多态性/氯吡格雷/经皮冠状动脉介入治疗/p-选择素/GPⅡb/Ⅲa纤维蛋白原受体Key words
gene polymorphism/clopidogrel/percutaneous coronary intervention/soluble P-selectin/platelet glycoprotein GPⅡb/Ⅲa fibrinogen receptor分类
医药卫生引用本文复制引用
马辉,吕慧怡,于晓杰,胡增春,孙丽晶,程荔春,张策..细胞色素P450 2C19基因多态性对氯吡格雷抗血小板作用的影响[J].中国临床药理学杂志,2017,33(19):1909-1911,3.
