中国临床药理学杂志2017，Vol.33Issue(20)：2005-2008,4.DOI:10.13699/j.cnki.1001-6821.2017.20.003
心舒宁胶囊联合康复训练治疗老年慢性心力衰竭的临床研究
Clinical trial of Xinshuning capsules combined with rehabilitation training in the treatment of chronic heart failure
摘要
Abstract
Objective To observe the clinical efficacy and safety of Xinshuning capsules combined with rehabilitation training in the treatment of chronic heart failure.Methods A total of 99 patients with chronic heart failure were randomly divided into control group (n =46 cases) and treatment group (n =53 cases).Control group received the rehabilitation training.Treatment group was given Xinshuning capsules 2.0-3.2 g,tid,oral,on the basis of control group.Two groups were treated for 8 weeks.The clinical efficacy,cardiac function and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates in treatment and control groups were 90.57％ (48 cases/53 cases) and 71.74％ (33 cases/46 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:left ventricular end systolic diameter were (31.94 ±4.68),(38.85 ±4.01)mm;left ventricular end diastolic diameter were (47.21 ± 7.81),(54.58--± 7.75) mm;left ventricular mass indexes were (58.84 ± 4.73) (52.37 ± 5.01) g · m-2;;left ventricular ejection fraction were (49.91 ± 6.95) ％,(44.23 ± 5.29) ％;left atrial diameter were (34.34 ± 6.27),(40.32 ± 6.52) mm,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in two groups were based on headache,gastrointestinal reactions,and rash.The incidences of adverse drug reactions in treatment and control groups were 5.66％ and 10.87％ without significant difference (P ＞ 0.05).Conclusion Xinshuning capsules combined with rehabilitation training have a definitive clinical efficacy in the treatment of chronic heart failure,which can improve the heart function,without increasing the incidence of adverse drug reactions.关键词
心舒宁胶囊/康复训练/慢性心力衰竭/安全性Key words
Xinshuning capsule/rehabilitation training/chronic heart failure/safety分类
医药卫生引用本文复制引用
马金,张艳,裴玮娜..心舒宁胶囊联合康复训练治疗老年慢性心力衰竭的临床研究[J].中国临床药理学杂志,2017,33(20):2005-2008,4.基金项目
河北省科学研究重点课题计划基金资助项目(ZL20140073) （ZL20140073）
