中国临床药理学杂志2017，Vol.33Issue(20)：2020-2022,2050,4.DOI:10.13699/j.cnki.1001-6821.2017.20.007
低分子肝素联合主动免疫治疗复发性自然流产的临床研究
Clinical trial of low molecular weight heparin combined with active immunotherapy in the treatment of recurrent spontaneous abortion
摘要
Abstract
Objective To investigate the effect of low molecular weight heparin combined with active immunization on patients with recurrent spontaneous abortion and its influences of hemodynamics.Methods A total of 92 cases of recurrent spontaneous abortion patients were randomly divided into treatment group (46 cases) and control group (46 cases).In control group,the lymphocytes of the patients' husbands were actively immunized.After pregnancy confirmed with blood β-human chorionic gonadotropin (β-HCG),the patients were administered of progesterone 40 mg,intramuscularly once a day until 14 weeks of gestation.The treatment group was treated with low molecular heparin calcium 5000 U,twice a day on the basis of control group until 24 h before termination of pregnancy.The clinical efficacy,the levels of β-HCG,progesterone and hemodynamics and the incidence of adverse drug reactions were observed before and after treatment.Results The clinical effective rate in treatment group was 95.65％ (44 cases/46 cases),had significant difference with that in control group,which was 76.09％ (35 cases/46 cases,P ＜0.05).After treatment,the levels of β-HCG in treatment group and control group were (6535.05 ± 54.34),(9845.50 ± 86.91) mU · mL-1,progesterone were (123.45 ±3.79),(93.24 ±5.18) nmol · L-1 (all P ＜0.05).After treatment,the blood viscosity,whole blood low shear viscosity and plasma viscosity in treatment group were (5.98 ± 0.52),(7.68 ± 0.51),(1.90 ± 0.34) mPa · s,had significant difference with those in control group,which were (7.78 ± 0.76),(9.18 ± 0.71),(2.30 ± 0.29) mPa · s (all P ＜ 0.05).In treatment group,there were 3 cases of erythema and itching in the injection site,2 cases of temporary vaginal bleeding,the incidence of adverse drug reactions was 10.87％ (5 cases/46 cases).There were 4 cases of erythema and itching in the injection site in control group,with incidence of 8.70％ (4cases/46 cases,P ＞ 0.05).Conclusion Low molecular weight heparin combined with active immunization has a significant effect on recurrent spontaneous abortion,and can improve the blood rheology.关键词
低分子肝素/主动免疫/复发性自然流产/血流动力学Key words
low molecular weight heparin/active immunization/recurrent spontaneous abortion/hemodynamics分类
医药卫生引用本文复制引用
闫志强,于春玲,莫培晖,唐梅,符爱贞..低分子肝素联合主动免疫治疗复发性自然流产的临床研究[J].中国临床药理学杂志,2017,33(20):2020-2022,2050,4.基金项目
海南省自然科学基金资助项目(813265) （813265）
