中国临床药理学杂志2017，Vol.33Issue(20)：2026-2028,3.DOI:10.13699/j.cnki.1001-6821.2017.20.009
维生素D3对耐氟康唑白念珠菌的协同抗菌活性
Synergistic activity of vitamin D3 against fluconazole-resistant isolates of Candida albicans
摘要
Abstract
Objective To investigate the in vitro antifungal activity of vitamin D3 against fluconazole-resistant Candida albicans.Methods The minimal inhibitory concentrations (MIC) of vitamin D3 against Candida albican were assayed by Clinical and Laboratory Standards Institute (CLSI) M27-A3 microdilution method;the combined antifungal activity of vitamin D3 with fluconazole was evaluated by broth microdilution checkerboard technique system.Results The MIC50 and MIC90 of vitamin D3 alone against Candida albican were 1,2 μg · mL-1 The combination of vitamin D3 and fluconazole had synergistic inhibitory activity against fluconazole-resistant Candida albican (80％,n =10) and MIC of fluconazole decreased from 64 μg mL-1 to 0.25 μg· mL-1,and no antagonism was found.Conclusion Results indicate that vitamin D3 had powerful antifungal activity against Candida albican,and enhanced the activity of fluconazole against fluconazole-resistant Candida albican in vitro.关键词
维生素D3/氟康唑/白念珠菌/体外药敏试验/协同效应Key words
vitamin D3/fluconazole/Candida albican/in vitro susceptibility/synergy activity分类
医药卫生引用本文复制引用
李亚丽,孙毅,陶小华,潘卫利..维生素D3对耐氟康唑白念珠菌的协同抗菌活性[J].中国临床药理学杂志,2017,33(20):2026-2028,3.基金项目
浙江省人民医院2016年优秀青年人员科研启动基金资助项目(ZRY2016C002) （ZRY2016C002）
