中国临床药理学杂志2017，Vol.33Issue(20)：2077-2080,4.DOI:10.13699/j.cnki.1001-6821.2017.20.023
伏立康唑用药安全性的评价
Review of the safety of voriconazole
魏栋 1张耀文 1陆文岐 2胡海棠 2刘芳2
作者信息
- 1. 中日友好医院感染管理办公室,北京100029
- 2. 丽珠医药集团股份有限公司,广东珠海519090
- 折叠
摘要
Abstract
Objective To evaluate the safety of clinical application of voriconazole.Methods The systematic literature search was limited to studies with publication dates before November 2014 and included the following databases:Chinese BioMedical Database (CBM),China National Knowledge Infrastructure (CNKI),Wanfang database,Cochrane Library and PubMed.Meta-analysis was conducted using MetaAnalyst 3.13,as well as the concerned outcomes of various types of adverse reactions/events.Results A total of 133 studies,including 34 case reports,were included.Of the 99 studies except the case reports,5065 people used voriconazole.Main types of adverse reactions/events were liver function impairment (13.5％),visual impairment (7.3％),digestive system impairment (5.1％),neurological impairment (4.8％),and skin impairment (4.3％),and severe adverse reactions/events were rare.Conclusion Adverse reactions/events of voriconazole are mainly liver impairment,visual impairment,digestive system impairment,neurological impairment and skin impairment,but the outcome is acceptable.Severe adverse reactions/event rates are rare.关键词
伏立康唑/安全性/系统评价Key words
voriconazole/safety/systematic review分类
医药卫生引用本文复制引用
魏栋,张耀文,陆文岐,胡海棠,刘芳..伏立康唑用药安全性的评价[J].中国临床药理学杂志,2017,33(20):2077-2080,4.
