中国免疫学杂志2017，Vol.33Issue(12)：1799-1803,5.DOI:10.3969/j.issn.1000-484X.2017.12.009
低氧诱导因子-1α在胃癌组织中表达水平及分子作用机制研究
Expression of HIF-1αin tissues of gastric cancer and molecular mechanism
马玉滨 1燕速 1于鹏杰 1白振忠1
作者信息
- 1. 青海大学附属医院胃肠肿瘤外科,西宁 810001
- 折叠
摘要
Abstract
Objective:To analyze the expression levels of the HIF-1αin the tissues of gastric cancer and the molecular mechanism in the pathogenesis of the gastric cancer .Methods:A total of 60 patients resided at the Hehuang valley in Qinghai province and diagnosed to gastric cancer were collected to plateau group .And the 60 patients resided at the plains (Shenzhen) and diagnosed to gastric cancer were collected to plains group .The specimens of gastric cancer in two groups were collected .The levels of HIF-1αprotein were detected by the SP method of the immunological histochemistry and compared between two groups .The levels of HIF-1αgene were detected by the RT-PCR and compared between two groups .And the levels of miR-210 were detected by the RT-PCR and compared between two groups .To analyze the relationship between the expression of HIF-1αand clinicopathological features in patients with gastric cancer.Results:The levels of HIF-1αprotein in plateau group were higher than in plains group (P<0.05).The levels of HIF-1αgene in plateau group were higher than in plains group (P<0.05).The levels of miR-210 in plateau group were higher than in plains group(P<0.05).The positive expression of HIF-1αin gastric cancer was related to tumor differentiation (P=0.0441),invasion depth (P=0.0319),lymph node metastasis(P=0.0253) and TNM staging(P=0.0289).Conclusion:The expression levels of the HIF-1αin the tissues of gastric cancer are upregulated under hypoxia environment , and the HIF-1αcan improve the development of the gastric cancer.关键词
低氧诱导因子-1α/胃癌/miR-210/分子机制Key words
Hypoxia inducible factor-1/Gastric cancer/miR-210/Molecular mechanism分类
医药卫生引用本文复制引用
马玉滨,燕速,于鹏杰,白振忠..低氧诱导因子-1α在胃癌组织中表达水平及分子作用机制研究[J].中国免疫学杂志,2017,33(12):1799-1803,5.
