中国免疫学杂志2017，Vol.33Issue(12)：1832-1837,6.DOI:10.3969/j.issn.1000-484X.2017.12.016
血清细胞因子IL-17与脱髓鞘性神经病多发性硬化相关性的研究:Meta分析
Correlation between serum cytokine IL-17 and demyelinating neuropathy multiple sclerosis:a Meta-analysis
摘要
Abstract
Objective:To evaluate the association with serum Interleukin-17 ( IL-17 ) and multiple sclerosis ( MS ) systematically evaluated .Methods:The retrieval words of "multiple sclerosis or MS"and "interleukin-17 or IL-17"were searched in PubMed,SpringerLink,Embases,OVID,China National Knowledge infrastructure (CNKI),Chinese VIP database,Chinese Biomedical Literature Database (CBM),Wan Fang Database through computer.Review Manager 5.3.was selected as the software edition.The time frame was ranged from January 1,2000 to March 10,2017.The language was not restricted .Results: Eventually 8 case-control studies were included with 544 cases.We found that the serum IL-17 level was associated with MS according to the weighted mean difference and 95%confidence interval ( WMD =38.65;95%CI:18.66 ,58.63 ) ,which had significant difference in statistics .Conclusion:The serum IL-17 level increases the risk of MS , suggesting that the serum IL-17 level can be used as a predictive biomarker for MS development and a target for MS effective prevention and treatment .关键词
白细胞介素17/脱髓鞘/中枢神经系统/多发性硬化/Meta分析Key words
Interleukin-17/Demyelination/Central nervous system/Multiple sclerosis/Meta-analysis分类
医药卫生引用本文复制引用
马金昀,张若曦,程晓东..血清细胞因子IL-17与脱髓鞘性神经病多发性硬化相关性的研究:Meta分析[J].中国免疫学杂志,2017,33(12):1832-1837,6.基金项目
本文受国家自然科学基金面上项目(No.81173630,No.81673669)和上海中医药大学中医学高峰学科建设项目(No.30304114323)资助. （No.81173630,No.81673669）
