中国免疫学杂志2017，Vol.33Issue(12)：1838-1842,5.DOI:10.3969/j.issn.1000-484X.2017.12.017
布鲁氏菌病患者中PD-1和PD-L1的表达
Expression of PD-1 and PD-L1 in patients infected with Brucella
摘要
Abstract
Objective:To investigate the roles of PD-1 and PD-L1,as well as related cytokines TGF-βand IL-10 in patients infected with Brucella.Methods:The expression of PD-1/PD-L1 in peripheral blood mononuclear cell CD 3+T cells,CD4+T cells,CD8+T cells,and dendrites cells was detected by flow cytometry in 60 patients infected with Brucella and 34 patients receiving follow-up cured and 60 healthy controls,the serum levels of TGF-βand IL-10 were detected by CBA.The correlations of PD-1 with TGF-βand IL-10 levels in patients infected with Brucella were analyzed by pearson correlation test .Results: Compared with control,brucellosis patients had the higher PD-1/PD-L1,TGF-βand IL-10 expression (P<0.05),while in the patients receiving follow-up cured,the PD-1/PD-L1,TGF-βand IL-10 were remarkably lower than those in pretherapy (P<0.01),the change of PD-1 was positively correlated with the levels of TGF-β(r=0.817,P<0.01) and IL-10 (r=0.835,P<0.01).Conclusion: High expression of PD-1/PD-L1 and TGF-βand IL-10 in patients with Brucella may be involved in the negative regulation of Brucella on host immune response .关键词
PD-1/PD-L1/布鲁氏菌病/细胞因子Key words
PD-1/PD-L1/Brucellosis/Cytokine分类
医药卫生引用本文复制引用
庞盼,张峰波,朱玥洁,贾斌,张跃新,张春桃,甫拉提·热西提,丁剑冰..布鲁氏菌病患者中PD-1和PD-L1的表达[J].中国免疫学杂志,2017,33(12):1838-1842,5.基金项目
本文为国家自然科学基金项目(81560322)、新疆维吾尔自治区自然科学基金项目(2015211C100)和新疆医科大学科学创新基金(XYDCX201507). （81560322）
