中国比较医学杂志2017，Vol.27Issue(12)：66-72,7.DOI:10.3969.j.issn.1671-7856.2017.12.012
中介素与肾上腺髓质素对局灶性脑缺血大鼠脑微循环的影响
Promoting effect of intermedin and adrenomedullin on cerebral microcirculation in rat models of cerebral ischemia
摘要
Abstract
Objective To explore the effect of intermedin ( IMD ) and adrenomedullin ( ADM ) on cerebral microcirculation in rats with cerebral ischemia. Methods Rat cerebral ischemia ( CI) model was established by middle cerebral artery occlusion. 40 SPF male adult Sprague-Dawley ( SD) rats were randomly divided into three groups:CI+NS ( normal saline) group, CI+ADM group and CI+IMD group, which were used to observe the changes of brain surface microcirculatory perfusion with a laser Doppler flowmeter. Results The differences of brain surface microcirculatory perfusion were statistically significant among the CI+NS group, CI+ADM group and CI+IMD group ( F=53. 426, P<0. 05 ) . Multiple comparison showed that the brain surface microcirculatory perfusion in the CI+IMD group was higher than that of the CI+NS group and CI+ADM group. Conclusions Intermedin can improve the cerebral microcirculation in rats with cerebral ischemia, and its therapeutic effect is better than adrenomedullin.关键词
中介素/肾上腺髓质素/脑缺血/微循环/大鼠Key words
Intermedin/Adrenomedullin/Cerebral Ischemia/Microcirculation/Rats分类
医药卫生引用本文复制引用
郭鑫,王静,王萌,路月英,贾娜娜,刘振刚,田景瑞,苑杰..中介素与肾上腺髓质素对局灶性脑缺血大鼠脑微循环的影响[J].中国比较医学杂志,2017,27(12):66-72,7.基金项目
河北省硕士研究生创新自助项目(CXZZSS2017072) （CXZZSS2017072）
华北理工大学研究生创新项目(2017S04) （2017S04）
河北省中医药管理局2016年度中医药类科研计划课题(2016079). （2016079）
