中国比较医学杂志2017，Vol.27Issue(12)：79-83,5.DOI:10.3969.j.issn.1671-7856.2017.12.014
白藜芦醇对大鼠血液高凝态的抑制作用及其与NF-κB表达的关系
Inhibitory effect of resveratrol on the hypercoagulable state in rats and its relationship with the expression of NF-κB
摘要
Abstract
Objective The topic of this study was to study the inhibitory effect of resveratrol on hypercoagulable state in rats and its relationship with the expression of NF-κB. Methods Rats were divided into control and model groups, and resveratrol ( high dose, 60 mg/kg ) , resveratrol ( low dose, 30 mg/kg ) and aspirin ( 10 mg/kg ) were given by intragastric administration for 7 d. Then, the rats were treated by adrenaline with ice bath or thrombin to generate hypercoagulable state. Blood samples were collected to test the prothrombin time (PT), activated partial thromboplastin time ( APTT) and blood viscosity. Vascular endothelial cells were collected to detect the expression of NF-κB by western blotting. Results PT and APTT values of rats in the control, resveratrol (high dose) and aspirin groups were significantly increased than the model group (P< 0. 05). Blood viscosity of rats in the control, resveratrol (high dose) and aspirin groups was significantly lower than the model group (P< 0. 05). The expression of NF-κB was decreased than that of the model group (P< 0. 05). Conclusions Resveratrol in high dose (60 mg/kg) can inhibit hypercoagulable state of rat, which may be related with its effect on decreasing the expression of NF-κB.关键词
白藜芦醇/高凝态/NF-κB/大鼠Key words
Resveratrol/Hypercoagulable state/NF-κB/Rats分类
医药卫生引用本文复制引用
王立文,沈晓洁,吴倩..白藜芦醇对大鼠血液高凝态的抑制作用及其与NF-κB表达的关系[J].中国比较医学杂志,2017,27(12):79-83,5.基金项目
无锡市医院管理中心科研项目(YGZXM1533). （YGZXM1533）
