摘要
Abstract
Objective To investigate the efficacy and safety of Alendronate for the treatment of glucocorticoid-induced spontaneous fractures in children.Methods Make an analysis of 3 children with spontaneous fractures cured after treatment with Alendronate in the Pediatric Department of Renal Rheumatism and Immunology of Shengjing Hospital affiliated to China Medical University.All of them undertook a prospective,self-compared study lasting 1 year.The 3 children,including 1 male and 2 female,were diagnosed respectively as mixed connective tissue disease (MTCD),refractory nephmtic syndrome (NS) and systemic lupus erythematosus (SLE).The onset of spontaneous fractures in these 3 children was at the 6th,4th and 6th month after GC treatment,the mean being (5.33±1.15)months.The onset age was 13,12 and 10 years old,respectively,the mean being (11.66± 1.52) years.After diagnosis of fracture,all the subjects were treated with GC reduction without affecting the primary disease and took Caltrate D600 2 pill qd,then Alendronate was given,70mg or 46.6mg per week orally,and they were interviewed every 3 months.Measure the BMD (bone mineral density) of spine,β-Crosslaps,osteocalcin,and bone imaging examination before the treatment and after the treatment at 3m,6m,9m and 1 year.Also,observe that whether or not the subjects had adverse reactions,such as nausea,vomiting or stomachache during the treatment in order to evaluate the therapeutic effect,safety and tolerance of oral Alendmnte.Results The clinical symptoms of the 3 cases disappeared quickly,and no adverse reactions were found after taking Alendronate.The relevant laboratory indicators were gradually improved as administration time extended,and no fractures occurred a second time.Conclusion Alendronate in the treatment of children with fracture induced by GC can significantly increase the BMD,degrade the bone transformational index,and has few side effects.It has satisfactory efficacy,safety and tolerance.关键词
阿仑膦酸钠/糖皮质激素/自发性骨折/儿童Key words
alendronate/glucocorticoid/spontaneous fracture/child分类
医药卫生
