中国现代医学杂志2017，Vol.27Issue(29)：6-10,5.DOI:10.3969/j.issn.1005-8982.2017.29.002
辣椒素抑制Lewis肺癌小鼠血管生成的实验研究
Inhibitory effect of capsaicin on angiogenesis in Lewis lung cancer of mice
李华洋 1许婧 1任公平 1姜爱英1
作者信息
- 1. 牡丹江医学院红旗医院,黑龙江 牡丹江 157011
- 折叠
摘要
Abstract
Objective To investigate the effect of capsaicin on angiogenesis in Lewis lung cancer of mice, and to discuss its possible mechanism. Methods The mice with transplanted Lewis lung cancer were randomly divided into 5 groups (9 in each): model group, low-dosage capsaicin group, medium-dosage capsaicin group, high-dosage capsaicin group, and positive control group. After continuous medication for 20 days, the mice were sacrificed. The tumor volume, tumor weight, tumor inhibitory rate and microvessel density (MVD) were compared among the 5 groups. The rate of CD34+ cells was detected by immunohistochemical analysis. The mRNA and protein expressions of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were detected by qRT-PCR and Western blot respectively. Results Capsaicin significantly inhibited the tumor volume and weight, MVD and the rate of CD34+ cells compared with the model group (P < 0.05). Capsaicin also significantly inhibited the mRNA and protein expressions of HIF-1α and VEGF in the Lewis lung cancer of mice compared with the model group (P < 0.05). Conclusions Capsaicin can inhibit tumor growth and angiogenesis in Lewis lung cancer of mice which might be related to the down-regulation of HIF-1α and VEGF.关键词
辣椒素/肺癌/血管生成/缺氧诱导因子1α/血管内皮生长因子Key words
capsaicin/lung cancer/angiogenesis/hypoxia-inducible factor-1α/vascular endothelial growth factor分类
医药卫生引用本文复制引用
李华洋,许婧,任公平,姜爱英..辣椒素抑制Lewis肺癌小鼠血管生成的实验研究[J].中国现代医学杂志,2017,27(29):6-10,5.
